Liu Huan, He Li
School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100000, China.
World J Diabetes. 2025 May 15;16(5):104937. doi: 10.4239/wjd.v16.i5.104937.
Diabetic wounds represent a significant challenge in the medical field, significantly impacting patient quality of life and imposing a heavy burden on healthcare systems. Intelligent hydrogel dressings have attracted significant attention in diabetic wound treatment due to their unique properties. This review systematically explores the three main categories of intelligent hydrogels (natural, synthetic, and composite), dissecting their composition, structure, and the mechanisms that enable their intelligent responses. The crucial roles of these dressings in maintaining a moist wound environment, efficiently absorbing exudate, and precisely delivering drugs are expounded. Moreover, their application advantages in combating bacteria and infections, regulating inflammation and immunity, promoting angiogenesis and tissue regeneration, as well as enabling real-time monitoring and personalized treatment, are explored in depth. Additionally, we discuss future research directions and the prospects for personalized precision medicine in diabetic wound care, aiming to inspire innovation and provide a comprehensive theoretical basis for the development of next-generation intelligent dressings.
糖尿病伤口是医学领域的一项重大挑战，严重影响患者生活质量，并给医疗系统带来沉重负担。智能水凝胶敷料因其独特性能在糖尿病伤口治疗中备受关注。本文综述系统探讨了智能水凝胶的三大主要类别（天然、合成和复合），剖析了它们的组成、结构以及实现智能响应的机制。阐述了这些敷料在维持伤口湿润环境、有效吸收渗出液和精确给药方面的关键作用。此外，还深入探讨了它们在对抗细菌和感染、调节炎症和免疫、促进血管生成和组织再生以及实现实时监测和个性化治疗方面的应用优势。此外，我们还讨论了糖尿病伤口护理中个性化精准医学的未来研究方向和前景，旨在激发创新，并为下一代智能敷料的开发提供全面的理论基础。
