每日三次或每8小时一次。
Three times daily or 8-hourly.
作者信息
Nigam R, Loveday B J, Grainger S L, Maxton D G
出版信息
J R Soc Med. 1986 Jan;79(1):15-6. doi: 10.1177/014107688607900105.
Abstract
The timing of drug ingestion over 24 hours was assessed in 58 outpatients taking drugs three times daily. The mean time between 1st and 2nd dose was 5.7 hours, 2nd and 3rd 6.1 hours and between 3rd and 1st of the next day 12.2 hours. Based on a simulation of hydralazine pharmacokinetics, such irregular administration would increase peak levels by 10% and decrease trough levels by 64% compared with regular 8-hourly doses.
摘要
对58名每日服用三次药物的门诊患者在24小时内的用药时间进行了评估。首剂和第二剂之间的平均时间为5.7小时，第二剂和第三剂之间为6.1小时，第三剂和次日首剂之间为12.2小时。基于对肼屈嗪药代动力学的模拟，与每8小时规律给药相比，这种不规律给药会使峰值水平提高10%，谷值水平降低64%。
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