同二聚体向异二聚体转变的建设性中性进化。

Constructive neutral evolution of homodimer to heterodimer transition.

作者信息

Chou Lin, Houghton Carly J, Wacholder Aaron, Carvunis Anne-Ruxandra

机构信息

Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA; Pittsburgh Center for Evolutionary Biology and Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

出版信息

Trends Biochem Sci. 2024 Dec;49(12):1036-1038. doi: 10.1016/j.tibs.2024.10.003. Epub 2024 Oct 23.

DOI:10.1016/j.tibs.2024.10.003

PMID:39448351

Abstract

Complexification of macrobiomolecules, such as homodimer to heterodimer transitions, are common during evolution. Is such complexification always adaptive? Using large-scale experiments and in-depth biochemical analyses, Després et al. recently demonstrated that an obligate heterodimer can evolve from a homodimer through neutral, nonadaptive events, and quantified key parameters required for such transitions.

摘要

大分子生物分子的复杂化，比如从同二聚体到异二聚体的转变，在进化过程中很常见。这种复杂化总是适应性的吗？通过大规模实验和深入的生化分析，德普雷等人最近证明，一个专性异二聚体可以通过中性的、非适应性事件从同二聚体进化而来，并量化了这种转变所需的关键参数。