Hospital General Regional 25, Mexican Social Security Institute, Mexico City 09100, Mexico.
Respiratory Department, Médica Sur Hospital, Mexico City 14050, Mexico.
Med Sci (Basel). 2024 Oct 4;12(4):52. doi: 10.3390/medsci12040052.
Chronic Obstructive Pulmonary Disease (COPD) is a disease characterized by local and systemic inflammation independently of the risk factor; during the exacerbations, such inflammation is accentuated and amplified. A practical inflammatory marker and one with an applicable predictive value in the follow-up has been sought. FeNO has shown an excellent performance in that respect within the context of asthma and has also been studied in tobacco-smoke COPD (COPD-TS). In Biomass-smoke COPD (COPD-BS), this, to our knowledge, has not been evaluated.
To measure FeNO levels in patients with COPD-BS and to compare these with those of patients with stable COPD-TS and in healthy controls.
Transversal, observational, descriptive, comparative, and analytical study. A total of 57 patients, including 23 with COPD-BS, 17 with COPD-TS, and 17 healthy control subjects. The measurement of FeNO was carried out on all of these by means of the on-line chemiluminescence technique; the values were expressed in parts per billion (ppb) for their analysis.
It was observed that the FeNO values were similar between COPD-BS and COPD-TS and were significantly different between the healthy and stable COPD (both groups). No correlation was found between pulmonary function and symptoms with FeNO in any of the groups.
The level of FeNO in stable COPD is found to be increased in a similar manner in COPD-BS and COPD-TS, with a significant difference on comparing it with that of the healthy subjects.
测量生物量烟雾 COPD（COPD-BS）患者的 FeNO 水平，并与稳定的 COPD-TS 患者和健康对照组进行比较。
这是一项横断面、观察性、描述性、比较性和分析性研究。共纳入 57 名患者，其中 23 名患有 COPD-BS，17 名患有 COPD-TS，17 名健康对照组。对所有患者采用在线化学发光技术进行 FeNO 测量，并以十亿分之几（ppb）表示进行分析。
观察到 COPD-BS 和 COPD-TS 之间的 FeNO 值相似，且与健康对照组相比差异显著（均为 P<0.001）。在任何一组中，均未发现肺功能和症状与 FeNO 之间存在相关性。
在稳定的 COPD 中，FeNO 水平在 COPD-BS 和 COPD-TS 中以相似的方式升高，与健康对照组相比差异显著。
