Menzies Daniel, Nair Arun, Lipworth Brian J
Asthma and Allergy Research Group, Dundee, Scotland, UK.
Chest. 2007 Feb;131(2):410-4. doi: 10.1378/chest.06-1335.
The measurement of fractional exhaled nitric oxide (FENO) can assist in the diagnosis of asthma and may also act as a useful surrogate inflammatory marker on which to base treatment decisions in asthma management algorithms. Until recently, this technique was confined to research facilities and secondary care institutions. A portable nitric oxide analyzer (MINO; Aerocrine AB; Smidesvägen, Sweden) has been developed, but few data exist comparing this device with established, larger laboratory-based analyzers (NIOX; Aerocrine AB).
A total of 101 asthmatic patients (64 treated with regular inhaled corticosteroids) and 50 healthy volunteers had simultaneous FENO measurements undertaken using NIOX and MINO devices.
In both asthmatic patients and healthy volunteers, there was a good correlation between the measurements obtained using each device (r = 0.94 and 0.96, respectively). Altman-Bland plots confirmed this agreement. Receiver operating characteristic curves discriminating asthmatic patients from healthy volunteers obtained using the NIOX and MINO showed a sensitivity of 83.2% and a specificity of 72% using cutoff values of 13 and 12.5 parts per billion, respectively.
FENO values obtained using a portable analyzer correlate well with those obtained using an established laboratory analyzer and can be used to discriminate asthmatic from nonasthmatic patients. This may facilitate the measurement of asthmatic airway inflammation in primary care.
呼出一氧化氮分数（FENO）的测量有助于哮喘的诊断，并且在哮喘管理算法中，也可作为制定治疗决策的有用替代炎症标志物。直到最近，这项技术还仅限于研究机构和二级医疗机构。一种便携式一氧化氮分析仪（MINO；瑞典阿可宁公司；斯米德斯韦根）已被开发出来，但将该设备与已有的、基于大型实验室的分析仪（NIOX；瑞典阿可宁公司）进行比较的数据很少。
共有101名哮喘患者（64名接受常规吸入糖皮质激素治疗）和50名健康志愿者使用NIOX和MINO设备同时进行FENO测量。
在哮喘患者和健康志愿者中，使用每种设备获得的测量值之间均具有良好的相关性（分别为r = 0.94和0.96）。阿尔特曼-布兰德图证实了这种一致性。使用NIOX和MINO区分哮喘患者与健康志愿者的受试者工作特征曲线显示，分别采用十亿分之13和12.5的临界值时，灵敏度为83.2%，特异性为72%。
使用便携式分析仪获得的FENO值与使用已有的实验室分析仪获得的值具有良好的相关性，并且可用于区分哮喘患者与非哮喘患者。这可能有助于在初级保健中测量哮喘气道炎症。
