Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, Jiangsu, China.
Institute of Medical Genetics and Reproductive Immunity, The Digestive and Reproductive System Cancers Precise Prevention Engineering Research Center of Jiangsu Province, Jiangsu College of Nursing, Huai'an 223002, Jiangsu, China.
J Immunol Res. 2024 Oct 17;2024:5577506. doi: 10.1155/2024/5577506. eCollection 2024.
B cells are essential for humoral immune response due to their ability to secrete antibodies. The development of B cells from the bone marrow to the periphery is tightly regulated by a complex set of immune signals, and each subset of B cells has a unique metabolic profile. Mitochondria, which serve as cellular energy powerhouses, play an essential role in regulating cell survival and immune responses. To maintain metabolic homeostasis, mitochondria dynamically adjust their morphology, distribution, and mass via biogenesis, fusion and fission, translocation, and mitophagy. Despite its extreme importance, the role of mitochondrial quality control (MQC) in B cells has not been thoroughly summarized, unlike in T cells. This article aims to review the mechanism of MQC that shapes B cell fate and functions. In addition, we will discuss the physiological and pathological implications of MQC in B cells, providing new insights into potential therapeutic targets for diseases associated with B cell abnormalities.
B 细胞对于体液免疫反应至关重要，因为它们能够分泌抗体。B 细胞从骨髓到外周的发育受到一系列复杂免疫信号的严格调控，并且每个 B 细胞亚群都具有独特的代谢特征。线粒体作为细胞的能量工厂，在调节细胞存活和免疫反应方面发挥着重要作用。为了维持代谢稳态，线粒体通过生物发生、融合和裂变、易位以及自噬来动态地调整其形态、分布和质量。尽管线粒体质量控制（MQC）在细胞中的作用非常重要，但与 T 细胞不同，其在 B 细胞中的作用尚未得到彻底总结。本文旨在综述塑造 B 细胞命运和功能的 MQC 机制。此外，我们还将讨论 MQC 在 B 细胞中的生理和病理意义，为与 B 细胞异常相关的疾病提供潜在治疗靶点的新见解。
