A Comprehensive Analysis of the Effect of Histological Subtypes on the Survival Probability of Kidney Carcinoma Patients: A Hypertabastic Survival Analysis.

The purpose of this study is two-fold. First, to find out whether the histological subtypes can serve as an independent prognostic factor for kidney carcinoma; and second, whether it's role can be maintained when we control for confounders. Using National Cancer Institute data from 1975-2016, we have modeled the impact of histological subtypes on the survival probability of kidney carcinoma patients. A total of 134,150 individuals were examined from the Surveillance, Epidemiology, and End Results program (SEER) [1]. The study variables are age, race/ethnicity, sex, tumor grade, type of surgery, geographical location of patient and stage of disease. We have applied the Hypertabastic proportional hazards survival model [2-6] to analyze the survival time of patients diagnosed with kidney carcinoma in order to explore the effect of histological subtypes on their survival probability. In particular, our intention was to assess the relationship between the histological subtypes and tumor stage, grade, and type of surgery. Our results indicated that histology plays an important role both when used as the sole predictor in the survival model ( < 0.001), as well as when controlling for confounding variables ( < 0.001).