Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.
Cells. 2024 Oct 18;13(20):1724. doi: 10.3390/cells13201724.
Astrocytes are essential for maintaining brain homeostasis. Alterations in their activity have been associated with various brain pathologies. Sex differences were reported to affect astrocyte development and activity, and even susceptibility to different neurodegenerative diseases. This review aims to summarize the current knowledge on the effects of sex on astrocyte activity in health and disease.
星形胶质细胞对于维持大脑内环境稳定至关重要。其活性改变与多种脑部疾病有关。有报道称,性别差异会影响星形胶质细胞的发育和活性,甚至影响对不同神经退行性疾病的易感性。本综述旨在总结目前关于性别对健康和疾病状态下星形胶质细胞活性影响的认识。