Duarte-Medrano Gilberto, Nuño-Lámbarri Natalia, Minutti-Palacios Marissa, Dominguez-Cherit Guillermo, Dominguez-Franco Analucia, La Via Luigi, Paternò Daniele Salvatore, Sorbello Massimiliano
Anesthesiology Department, Medica Sur Clinic & Foundation, Mexico City 14050, Mexico.
Translational Research Unit, Medica Sur Clinic & Foundation, Mexico City 14050, Mexico.
Healthcare (Basel). 2024 Oct 12;12(20):2029. doi: 10.3390/healthcare12202029.
One potential complication in bariatric surgery is rhabdomyolysis, which is a condition involving muscle tissue damage that can significantly impact a patient's health. The causes of rhabdomyolysis can be broadly classified into two major categories: traumatic and non-traumatic. Early investigations into the development of intraoperative rhabdomyolysis in bariatric surgery identified the main risk factors as tissue compression-primarily affecting the lower extremities, gluteal muscles, and lumbar region-as well as prolonged periods of immobilization. Clinically, rhabdomyolysis is typically suspected when a patient presents with muscle pain, weakness, and potentially dark urine or even anuria. However, the most reliable biomarker for rhabdomyolysis is elevated serum creatine kinase levels. The primary goal in managing hydration is to correct intravascular volume depletion, with solutions such as Lactated Ringer's or 0.9% saline being appropriate options for resuscitation. Perioperative diagnosis of rhabdomyolysis poses a significant challenge for anesthesiologists, requiring a high degree of clinical suspicion, particularly in bariatric patients. In this vulnerable population, prevention is crucial. The success of treatment depends on its early initiation; however, there are still significant limitations in the therapies available to prevent renal injury secondary to rhabdomyolysis.
减重手术的一个潜在并发症是横纹肌溶解症,这是一种涉及肌肉组织损伤的病症,会对患者健康产生重大影响。横纹肌溶解症的病因可大致分为两大类:创伤性和非创伤性。早期对减重手术中术中横纹肌溶解症发生情况的调查确定主要危险因素为组织受压——主要影响下肢、臀肌和腰部区域——以及长时间固定不动。临床上,当患者出现肌肉疼痛、无力,以及可能出现深色尿液甚至无尿时,通常会怀疑发生了横纹肌溶解症。然而,横纹肌溶解症最可靠的生物标志物是血清肌酸激酶水平升高。管理补液的主要目标是纠正血管内容量耗竭,乳酸林格氏液或0.9%生理盐水等溶液是复苏的合适选择。横纹肌溶解症的围手术期诊断对麻醉医生构成重大挑战,需要高度的临床怀疑,尤其是在减重患者中。在这个脆弱的人群中,预防至关重要。治疗的成功取决于早期开始;然而,在预防横纹肌溶解症继发肾损伤的现有疗法中仍存在重大局限性。