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CRISPR技术在植物基因编辑中用于提高对生物因子耐受性的应用：一项系统综述

Use of CRISPR Technology in Gene Editing for Tolerance to Biotic Factors in Plants: A Systematic Review.

作者信息

Mascarenhas Marcelly Santana, Nascimento Fernanda Dos Santos, Rocha Anelita de Jesus, Ferreira Mileide Dos Santos, Oliveira Wanderley Diaciso Dos Santos, Morais Lino Lucymeire Souza, Mendes Tiago Antônio de Oliveira, Ferreira Claudia Fortes, Santos-Serejo Janay Almeida Dos, Amorim Edson Perito

机构信息

Department of Biological Sciences, Feira de Santana State University, Feira de Santana 44036-900, BA, Brazil.

Embrapa Mandioca e Fruticultura, Cruz das Almas 44380-000, BA, Brazil.

出版信息

Curr Issues Mol Biol. 2024 Oct 2;46(10):11086-11123. doi: 10.3390/cimb46100659.

DOI:10.3390/cimb46100659
PMID:39451539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11505962/
Abstract

The objective of this systematic review (SR) was to select studies on the use of gene editing by CRISPR technology related to plant resistance to biotic stresses. We sought to evaluate articles deposited in six electronic databases, using pre-defined inclusion and exclusion criteria. This SR demonstrates that countries such as China and the United States of America stand out in studies with CRISPR/Cas. Among the most studied crops are rice, tomatoes and the model plant . The most cited biotic agents include the genera, and . This SR also identifies several CRISPR/Cas-edited genes and demonstrates that plant responses to stressors are mediated by many complex signaling pathways. The Cas9 enzyme is used in most articles and Cas12 and 13 are used as additional editing tools. Furthermore, the quality of the articles included in this SR was validated by a risk of bias analysis. The information collected in this SR helps to understand the state of the art of CRISPR/Cas aimed at improving resistance to diseases and pests to understand the mechanisms involved in most host-pathogen relationships. This SR shows that the CRISPR/Cas system provides a straightforward method for rapid gene targeting, providing useful information for plant breeding programs.

摘要

本系统评价（SR）的目的是筛选关于利用CRISPR技术进行基因编辑与植物抗生物胁迫相关的研究。我们依据预先设定的纳入和排除标准，在六个电子数据库中检索相关文章。本系统评价表明，中国和美国等国家在CRISPR/Cas研究方面表现突出。研究最多的作物包括水稻、番茄和模式植物。引用最多的生物因子包括某些属。本系统评价还鉴定了多个经CRISPR/Cas编辑的基因，并表明植物对胁迫源的反应由许多复杂的信号通路介导。大多数文章使用Cas9酶，Cas12和Cas13用作额外的编辑工具。此外，本系统评价纳入文章的质量通过偏倚风险分析得到验证。本系统评价收集的信息有助于了解旨在提高抗病虫能力的CRISPR/Cas技术的现状，以及了解大多数宿主-病原体关系中涉及的机制。本系统评价表明，CRISPR/Cas系统为快速基因靶向提供了一种直接的方法，为植物育种计划提供了有用信息。

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BMC Plant Biol. 2024 Aug 10;24(1):763. doi: 10.1186/s12870-024-05428-3.
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E3 ligase SlCOP1-1 stabilizes transcription factor SlOpaque2 and enhances fruit resistance to Botrytis cinerea in tomato.E3 连接酶 SlCOP1-1 稳定转录因子 SlOpaque2，增强番茄果实对灰葡萄孢的抗性。
Plant Physiol. 2024 Oct 1;196(2):1196-1213. doi: 10.1093/plphys/kiae404.
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Evolutionarily conserved 12-oxophytodienoate reductase -lncRNA pair affects disease resistance in tea () via the jasmonic acid signaling pathway.
进化保守的12-氧代植物二烯酸还原酶-lncRNA对通过茉莉酸信号通路影响茶树的抗病性。
Hortic Res. 2024 May 6;11(7):uhae129. doi: 10.1093/hr/uhae129. eCollection 2024 Jul.
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A NAC transcription factor MNAC3-centered regulatory network negatively modulates rice immunity against blast disease.一个以NAC转录因子MNAC3为中心的调控网络对水稻稻瘟病抗性起负调控作用。
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CRISPR/Cas9-mediated knockout of NtMYC2a gene involved in resistance to bacterial wilt in tobacco.CRISPR/Cas9 介导的烟草 NtMYC2a 基因敲除与抗细菌性萎蔫病有关。
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