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新型基于布鲁顿酪氨酸激酶(Btk)的制剂BLB1和Lip对水生非靶标生物的影响。

Effects of New Btk-Based Formulations BLB1 and Lip on Aquatic Non-Target Organisms.

作者信息

Dhaouadi Sayda, Jeni Rim El, Kraiem Hazar, Ayyildiz Gul, Filik-Iscen Cansu, Yurtkuran-Ceterez Zeynep, Bouhaouala-Zahar Balkiss

机构信息

Laboratoire des Biomolécules, Venins et Applications Théranostiques, Equipe NanoBioMedika, Institut Pasteur de Tunis, Université Tunis-El Manar, 13 Place Pasteur, BP74, Belvédère, Tunis 1002, Tunisia.

Biyans Biyolojik ÜRÜNLER AR-GE DAN. SAN. TİC.LTD.ŞTİ., Mustafa Kemal Mah. Dumlupinar BLV.NO: 280: G İÇ KAPI NO: 1260, Çankaya 06530, Turkey.

出版信息

Biology (Basel). 2024 Oct 14;13(10):824. doi: 10.3390/biology13100824.

DOI:10.3390/biology13100824
PMID:39452133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11505242/
Abstract

Integrated pest management based on the use of biopesticides is largely applied. Experimental bioassays are critical to assess biopesticide biosafety at the ecotoxicological level. In this study, we investigated the effects of the new ()-formulated-based biopesticides BLB1 and Lip, efficiently tested in field assays (IPM-4-CITRUS EC project no. 734921) on two aquatic non-target organisms, precisely the water flea and the bioluminescent bacteria . Acute toxicity studies, carried out in a comparative manner with Delfin as the reference bioproduct and the lactose-based Blank formulation, show that no significant toxicity was observed up to 1 g/L. Our results indicated that BLB1- and Lip-formulated new bioproducts are far less toxic than the Delfin reference bioproduct.

摘要

基于生物农药使用的综合虫害管理得到了广泛应用。实验生物测定对于在生态毒理学水平评估生物农药生物安全性至关重要。在本研究中,我们调查了在田间试验(IPM - 4 - CITRUS EC项目编号734921)中高效测试的新型()配方生物农药BLB1和Lip对两种水生非靶标生物,即水蚤和发光细菌的影响。以Delfin作为参考生物产品和基于乳糖的空白配方进行比较的急性毒性研究表明,在高达1 g/L的浓度下未观察到明显毒性。我们的结果表明,BLB1和Lip配方的新型生物产品的毒性远低于Delfin参考生物产品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7b/11505242/2115da46f3cd/biology-13-00824-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7b/11505242/eaac04119cfa/biology-13-00824-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7b/11505242/c6f770884434/biology-13-00824-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7b/11505242/b6d10833f274/biology-13-00824-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7b/11505242/2dc4e2c0135a/biology-13-00824-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7b/11505242/23a0c72260cf/biology-13-00824-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7b/11505242/2115da46f3cd/biology-13-00824-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7b/11505242/eaac04119cfa/biology-13-00824-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7b/11505242/c6f770884434/biology-13-00824-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7b/11505242/b6d10833f274/biology-13-00824-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7b/11505242/2dc4e2c0135a/biology-13-00824-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7b/11505242/23a0c72260cf/biology-13-00824-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7b/11505242/2115da46f3cd/biology-13-00824-g006.jpg

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