Anueyiagu Kenneth Nnamdi, Agu Chibuzor Gerald, Umar Uzal, Lopes Bruno Silvester
Department of Public Health Technology, Federal College of Animal Health and Production Technology, Vom 200273, Nigeria.
National Veterinary Research Institute, Vom 930103, Nigeria.
Antibiotics (Basel). 2024 Sep 26;13(10):922. doi: 10.3390/antibiotics13100922.
is a gram-negative commensal bacterium living in human and animal intestines. Its pathogenic strains lead to high morbidity and mortality, which can adversely affect people by causing urinary tract infections, food poisoning, septic shock, or meningitis. Humans can contract by eating contaminated food-such as raw or undercooked raw milk, meat products, and fresh produce sold in open markets-as well as by coming into contact with contaminated settings like wastewater, municipal water, soil, and faeces. Some pathogenic strains identified in Nigeria, include Enterohemorrhagic (Verotoxigenic), Enterotoxigenic, Enteropathogenic, Enteroinvasive, and Enteroaggregative . This causes acute watery or bloody diarrhoea, stomach cramps, and vomiting. Apart from the virulence profile of , antibiotic resistance mechanisms such as the presence of found in humans, animals, and environmental isolates are of great importance and require surveillance and monitoring for emerging threats in resource-limited countries. This review is aimed at understanding the underlying mechanisms of evolution and antibiotic resistance in in Nigeria and highlights the use of improving One Health approaches to combat the problem of emerging infectious diseases.
是一种生活在人和动物肠道中的革兰氏阴性共生细菌。其致病菌株导致高发病率和死亡率，可通过引起尿路感染、食物中毒、败血症性休克或脑膜炎对人产生不利影响。人类可通过食用受污染的食物（如生的或未煮熟的生牛奶、肉制品以及露天市场出售的新鲜农产品）以及接触受污染的环境（如废水、市政供水、土壤和粪便）而感染。在尼日利亚发现的一些致病菌株包括肠出血性（产志贺毒素）、产肠毒素、肠致病性、肠侵袭性和肠聚集性。这会导致急性水样或血性腹泻、胃痉挛和呕吐。除了的毒力特征外，在人类、动物和环境分离株中发现的抗生素耐药机制（如的存在）也非常重要，并且在资源有限的国家需要对新出现的威胁进行监测。本综述旨在了解尼日利亚中进化和抗生素耐药性的潜在机制，并强调利用改进的“同一健康”方法来应对新出现的传染病问题。
