Bakr El-Nassan Hala
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Pharm Dev Technol. 2024 Dec;29(10):1084-1092. doi: 10.1080/10837450.2024.2421786. Epub 2024 Nov 4.
Deep eutectic solvents (DESs) are green alternatives to ionic liquids with wide applications in organic synthesis and catalysis. DESs are characterized by being easily prepared, biodegradable, nontoxic, and noninflammable. When one or more of the DES components is active pharmaceutical ingredient (API), the eutectic mixtures are named as therapeutic deep eutectic solvents (THEDESs). THEDESs are prepared in order to improve the solubility and/or the permeability of the APIs. This review presents a brief summary of the most important THEDESs reported to date having antimicrobial and/or anticancer activities. The challenges and limitations of THEDES preparation were also discussed. The work presented here indicated the importance of THEDES as a promising drug delivery system that can overcome the bioavailability problems while retaining or enhancing the biological activity of its components.
低共熔溶剂（DESs）是离子液体的绿色替代品，在有机合成和催化领域有广泛应用。DESs的特点是易于制备、可生物降解、无毒且不易燃。当DES的一种或多种成分是活性药物成分（API）时，这种共熔混合物就被称为治疗性低共熔溶剂（THEDESs）。制备THEDESs是为了提高API的溶解度和/或渗透性。本文综述了迄今为止报道的具有抗菌和/或抗癌活性的最重要的THEDESs。还讨论了THEDESs制备过程中的挑战和局限性。本文的研究表明，THEDES作为一种有前景的药物递送系统非常重要，它可以在保留或增强其成分生物活性的同时克服生物利用度问题。
