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巴西成年人群非甾体抗炎药和抗生素消费情况研究:一项队列研究

Study on the Consumption of Non-Steroidal Anti-Inflammatory Drugs and Antibiotics by the Brazilian Adult Population: A Cohort Study.

作者信息

Pedrolongo Douglas Araujo, Sagioneti Fernanda Teixeira, Weckwerth Giovana Maria, Oliveira Gabriela Moraes, Santos Carlos Ferreira, Calvo Adriana Maria

机构信息

Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru 17012-901, Brazil.

Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru 17012-900, Brazil.

出版信息

Pharmacy (Basel). 2024 Sep 29;12(5):150. doi: 10.3390/pharmacy12050150.

Abstract

Self-medication without a medical or dental prescription is an action that leads to a significant problems associated with the overuse of medication in Brazil. The inappropriate use of antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) leads to problems related to microbial agent resistance and gastrointestinal complications. The purpose of this study was to elucidate the patterns of antibiotic and NSAIDs consumption among the adult population of Brazil. The questionnaire was answered by 400 people residing in Brazil who had access to the link in the year 2023. The findings showed that approximately 89.5% of the volunteers had used NSAIDs, and 32.2% had used antibiotics whether or not these medications had been prescribed by doctors or dentists. It was noted that a large proportion of the adverse effects reported by the volunteers involved symptoms related to gastrointestinal complaints. There was a high prevalence of NSAIDs consumption in the studied population, which is consistent with the high frequency of risk of adverse reactions caused by these drugs, particularly in the gastrointestinal tract. In relation to antibiotics, it was observed that the non-prescription consumption of these medications by the population was considered high, reaching one-third of the total number of volunteers who consumed such medications.

摘要

在没有医生或牙医处方的情况下自行用药,这种行为在巴西会导致与药物过度使用相关的重大问题。抗生素和非甾体抗炎药(NSAIDs)的不当使用会引发微生物耐药性和胃肠道并发症等问题。本研究的目的是阐明巴西成年人群中抗生素和NSAIDs的消费模式。居住在巴西且在2023年能够访问该链接的400人回答了问卷。研究结果显示,约89.5%的志愿者使用过NSAIDs,32.2%的志愿者使用过抗生素,无论这些药物是否由医生或牙医开具。值得注意的是,志愿者报告的大部分不良反应都涉及与胃肠道不适相关的症状。在所研究的人群中,NSAIDs的消费率很高,这与这些药物引起不良反应的高风险频率一致,尤其是在胃肠道方面。关于抗生素,观察到人群中非处方使用这些药物的情况被认为较高,达到使用此类药物的志愿者总数的三分之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0e5/11510564/2c25e252a33b/pharmacy-12-00150-g001.jpg

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