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作为疫苗的重组痘苗病毒。

Recombinant vaccinia viruses as vaccines.

作者信息

Brown F, Schild G C, Ada G L

出版信息

Nature. 1986;319(6054):549-50. doi: 10.1038/319549a0.

DOI:10.1038/319549a0
PMID:3945343
Abstract

The prospect of live vaccines consisting of genetically modified vaccinia virus expressing foreign genes is exciting, but important issues concerning safety and efficacy need to be resolved.

摘要

由表达外源基因的基因改造痘苗病毒组成的活疫苗前景令人兴奋，但有关安全性和有效性的重要问题有待解决。

相似文献

1
Recombinant vaccinia viruses as vaccines.作为疫苗的重组痘苗病毒。
Nature. 1986;319(6054):549-50. doi: 10.1038/319549a0.
2
Vaccination of infant macaques with a recombinant modified vaccinia virus Ankara expressing the respiratory syncytial virus F and G genes does not predispose for immunopathology.用表达呼吸道合胞病毒F和G基因的重组改良安卡拉痘苗病毒对幼年猕猴进行疫苗接种不会引发免疫病理学问题。
Vaccine. 2004 Feb 25;22(8):923-6. doi: 10.1016/j.vaccine.2003.10.010.
3
Improved protection against simian immunodeficiency virus mucosal challenge in macaques primed with a DNA vaccine and boosted with the recombinant modified vaccinia virus Ankara and recombinant Semliki Forest virus.用DNA疫苗初免并用重组改良安卡拉痘病毒和重组塞姆利基森林病毒加强免疫的猕猴对猿猴免疫缺陷病毒黏膜攻击的保护作用增强。
Vaccine. 2008 Jan 24;26(4):532-45. doi: 10.1016/j.vaccine.2007.11.025. Epub 2007 Dec 3.
4
[Isolation of a recombinant vaccinia virus based on the LIVP strain inducing the surface antigen of the hepatitis B virus].[基于诱导乙肝病毒表面抗原的LIVP株的重组痘苗病毒的分离]
Dokl Akad Nauk SSSR. 1985;285(3):696-9.
5
Live vaccinia-rabies virus recombinants, but not an inactivated rabies virus cell culture vaccine, protect B-lymphocyte-deficient A/WySnJ mice against rabies: considerations of recombinant defective poxviruses for rabies immunization of immunocompromised individuals.活痘苗 - 狂犬病病毒重组体，而非灭活的狂犬病病毒细胞培养疫苗，可保护B淋巴细胞缺陷的A/WySnJ小鼠免受狂犬病侵害：关于用于免疫功能低下个体狂犬病免疫的重组缺陷痘病毒的思考。
Vaccine. 2004 Sep 3;22(25-26):3329-33. doi: 10.1016/j.vaccine.2004.02.039.
6
[The use of the gene responsible for formation of hemorrhage as a phenotypic marker in creating hybrid variations of vaccinia virus].[将负责出血形成的基因用作表型标记以创建痘苗病毒杂交变体]
Dokl Akad Nauk SSSR. 1989;305(5):1246-8.
7
Poxviruses as vaccine vectors.痘病毒作为疫苗载体。
Comp Immunol Microbiol Infect Dis. 2003 Oct;26(5-6):343-55. doi: 10.1016/S0147-9571(03)00019-5.
8
Microarray assay for evaluation of the genetic stability of modified vaccinia virus Ankara B5R gene.用于评估安卡拉痘苗病毒B5R基因修饰后遗传稳定性的微阵列分析
J Med Virol. 2007 Jun;79(6):791-802. doi: 10.1002/jmv.20889.
9
Dominant host range selection of vaccinia recombinants by rescue of an essential gene.通过拯救必需基因对痘苗重组体进行主要宿主范围选择。
Virology. 1998 Sep 15;249(1):160-6. doi: 10.1006/viro.1998.9307.
10
[Construction of recombinant vaccinia virus expressing HSV-2 gD gene as live recombinant vaccine strain].[构建表达单纯疱疹病毒2型糖蛋白D基因的重组痘苗病毒作为重组活疫苗株]
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1997 Mar;11(1):16-20.

引用本文的文献

1
Emerging viruses and current strategies for vaccine intervention.新兴病毒与疫苗干预的现行策略。
Clin Exp Immunol. 2019 May;196(2):157-166. doi: 10.1111/cei.13295.
2
Rational approaches to immune regulation.免疫调节的合理方法。
Immunol Res. 1998;17(1-2):191-207. doi: 10.1007/BF02786444.
3
Association of non-viral proteins with recombinant vaccinia virus virions.非病毒蛋白与重组痘苗病毒病毒粒子的关联。
Arch Virol. 1987;94(3-4):347-51. doi: 10.1007/BF01310729.
4
Expression of the firefly luciferase gene in vaccinia virus: a highly sensitive gene marker to follow virus dissemination in tissues of infected animals.萤火虫荧光素酶基因在痘苗病毒中的表达：一种用于追踪病毒在感染动物组织中传播的高度敏感的基因标记物。
Proc Natl Acad Sci U S A. 1988 Mar;85(5):1667-71. doi: 10.1073/pnas.85.5.1667.
5
Human poxvirus infection after the eradication of smallpox.天花根除后的人类痘病毒感染。
Epidemiol Infect. 1988 Jun;100(3):321-34. doi: 10.1017/s0950268800067078.
6
Evaluation of pseudorabies virus glycoprotein gp50 as a vaccine for Aujeszky's disease in mice and swine: expression by vaccinia virus and Chinese hamster ovary cells.伪狂犬病病毒糖蛋白gp50作为小鼠和猪奥耶斯基氏病疫苗的评价：由痘苗病毒和中国仓鼠卵巢细胞表达
J Virol. 1987 Dec;61(12):3977-82. doi: 10.1128/JVI.61.12.3977-3982.1987.
7
Characterization of virulent and attenuated strains of pseudorabies virus for thymidine kinase activity, virulence and restriction patterns.伪狂犬病病毒强毒株和弱毒株的胸苷激酶活性、毒力及限制性酶切图谱特征分析
Can J Vet Res. 1987 Jul;51(3):334-9.
8
A single point mutation of Ala-25 to Asp in the 14,000-Mr envelope protein of vaccinia virus induces a size change that leads to the small plaque size phenotype of the virus.痘苗病毒14000道尔顿包膜蛋白中Ala - 25突变为Asp的单点突变会导致大小变化，从而产生该病毒的小蚀斑大小表型。
J Virol. 1989 Nov;63(11):4507-14. doi: 10.1128/JVI.63.11.4507-4514.1989.
9
Highly attenuated vaccinia virus mutants for the generation of safe recombinant viruses.用于产生安全重组病毒的高度减毒痘苗病毒突变体。
Proc Natl Acad Sci U S A. 1989 Feb;86(4):1287-91. doi: 10.1073/pnas.86.4.1287.
10
IPTG-dependent vaccinia virus: identification of a virus protein enabling virion envelopment by Golgi membrane and egress.异丙基-β-D-硫代半乳糖苷（IPTG）依赖性痘苗病毒：一种能使病毒粒子被高尔基体膜包裹并释放的病毒蛋白的鉴定。
Nucleic Acids Res. 1990 Sep 25;18(18):5347-51. doi: 10.1093/nar/18.18.5347.