Niv D, Rudick V, Golan A, Chayen M S
Obstet Gynecol. 1986 Feb;67(2):206-9. doi: 10.1097/00006250-198602000-00009.
The analgesic properties and motor effect of epidural 0.25% bupivacaine (8 mL) were compared with those of epidural morphine (2 mg in 10 mL saline) followed by 8 mL of 0.25% bupivacaine. The study was performed on two groups of parturients (30 in each group) in active labor. Pain relief in the morphine-bupivacaine group lasted for a mean of 131.1 minutes (SD +/- 49.8) as opposed to the plain bupivacaine group -57 minutes (SD +/- 15.28). Satisfaction from analgesia in the morphine-bupivacaine group was higher as well. Motor involvement was not seen in either group. Perineal pain relief in the postpartum period lasted for a mean of 16 hours and 40 minutes in the morphine-bupivacaine group. It was concluded that the concomitant use of epidural morphine augmented the analgesic effect of 0.25% bupivacaine without motor effect.
将硬膜外注射0.25%布比卡因(8毫升)的镇痛特性及运动效应,与硬膜外注射吗啡(2毫克溶于10毫升生理盐水中)后再注射8毫升0.25%布比卡因的情况进行了比较。该研究在两组处于活跃期分娩的产妇(每组30人)中进行。吗啡-布比卡因组的疼痛缓解平均持续131.1分钟(标准差±49.8),而单纯布比卡因组为57分钟(标准差±15.28)。吗啡-布比卡因组的镇痛满意度也更高。两组均未出现运动功能受累情况。吗啡-布比卡因组产后会阴部疼痛缓解平均持续16小时40分钟。得出的结论是,硬膜外注射吗啡与0.25%布比卡因联合使用可增强镇痛效果且不产生运动效应。