Pseudo-widening of cranial sutures as a feature of long-term prostaglandin E1 therapy.

Disturbance of desmogenous ossification of the skull is an extremely rare complication of long-term prostaglandin treatment. This report describes a newborn with pulmonary atresia, ventricular septal defect and ductus-dependent pulmonary blood flow in whom administration of prostaglandin E1 (PGE1) over a period of 96 days produced uncommon clinical and radiologic findings.