Sebrechts M M, Shaywitz S E, Shaywitz B A, Jatlow P, Anderson G M, Cohen D J
Pediatrics. 1986 Feb;77(2):222-8.
In this study we analyzed some of the cognitive components that may constitute attention deficit disorder. It consisted of a double-blind, drug-placebo study of 12 children being treated with three doses of methylphenidate and placebo. Results of an attentional test battery, teacher and parent ratings, and blood levels of methylphenidate are reported. In general, performance was best with 0.6 mg/kg of methylphenidate (the highest dose tested) and worst with placebo. It is argued that no single test provides a complete assessment of attentional deficits and that methylphenidate can improve performance by affecting the allocation of cognitive resources to a task.
在本研究中，我们分析了一些可能构成注意力缺陷障碍的认知成分。该研究为双盲、药物-安慰剂研究，对12名儿童使用三种剂量的哌甲酯及安慰剂进行治疗。报告了注意力测试组、教师和家长评分以及哌甲酯血药浓度的结果。总体而言，使用0.6mg/kg哌甲酯（测试的最高剂量）时表现最佳，使用安慰剂时表现最差。有人认为，没有单一测试能对注意力缺陷进行全面评估，且哌甲酯可通过影响认知资源在任务中的分配来提高表现。
