Xiangya Stomatological Hospital, Central South University, Changsha, Hunan, P.R. China.
J Leukoc Biol. 2022 Feb;111(2):469-476. doi: 10.1002/JLB.3MR0521-763RR. Epub 2021 Jun 14.
Oral submucous fibrosis (OSF) is a chronic, progressive, scarring, and premalignant disease of the oral mucosa. Its pathogenic factors are complex and include chewing areca nuts or other spicy food items, nutrition, and genetic and immune factors. Recently, immune factors have become the focus of medical research, with increased attention being paid to the role of immune regulation in diseases, particularly tumors. OSF is accompanied by obvious changes in the immune microenvironment. The aim of this review is to discuss the potential relationship of OSF and areca nuts genetic with the immune system, including lymphocytes, macrophage, Langerhans cell, mast cell, and substances released by activated immune cells, to determine the pathogenesis and treatment of OSF from an immunologic viewpoint.
口腔黏膜下纤维性变（OSF）是一种慢性、进行性、瘢痕化和癌前病变的口腔黏膜疾病。其发病因素复杂，包括咀嚼槟榔或其他辛辣食物、营养、遗传和免疫因素。近年来，免疫因素已成为医学研究的焦点，免疫调节在疾病尤其是肿瘤中的作用受到越来越多的关注。OSF 伴有明显的免疫微环境变化。本综述旨在讨论 OSF 和槟榔遗传与免疫系统之间的潜在关系，包括淋巴细胞、巨噬细胞、朗格汉斯细胞、肥大细胞和激活免疫细胞释放的物质，从免疫学角度探讨 OSF 的发病机制和治疗方法。
