Department of Neurology, Faculty of Medicine, Istanbul Atlas University, 34408 Istanbul, Turkey.
Department of Medical Biochemistry, Faculty of Medicine, Istanbul Atlas University, 34408 Istanbul, Turkey.
Biomolecules. 2024 Oct 10;14(10):1279. doi: 10.3390/biom14101279.
The aim was to evaluate the value of otolith-associated protein otoconin-90 (OC90) and otolin-1 in the pathogenesis research and clinical treatment of benign paroxysmal positional vertigo (BPPV).
The study included 50 patients with BPPV admitted to neurology and otorhinolaryngology departments and 30 healthy subjects with no history of dizziness as a control group.
BPPV and controls were similar in terms of gender and age. Otolin-1 concentration was significantly greater in the BPPV group than in the controls (710.44 [584.35-837.39] vs 280.45 [212.7-419.61]; < 0.001). No statistical significance was found, although OC90 was higher in the BPPV group than in the controls. There was a strong positive correlation between otolin-1 and OC90, a moderate negative correlation between otolin-1 and vitamin D, and a strong negative correlation between OC90 and vitamin D in the BPPV patient group. Otolin-1 had high specificity and AUC values for BPPV (AUC: 0.933; 95% CI: 0.881-0.986, 79.2% sensitivity, 100% specificity with a cutoff greater than 525).
High serum concentrations of otolin-1 were associated with an increased risk of BPPV, but high concentrations of OC90 were not. Serum concentrations of otolin-1 can potentially be used as a biomarker for the acute onset of inner ear disorders due to the significant increase in patients with BPPV. Vitamin D has high specificity and sensitivity in patients with BPPV. It also provides evidence that BPPV patients with vitamin D deficiency may improve their symptoms with replacement therapy. More large-scale prospective studies are required to confirm these associations and clarify the exact mechanisms.
评估耳石相关蛋白耳石蛋白-90（OC90）和耳石蛋白-1 在良性阵发性位置性眩晕（BPPV）发病机制研究和临床治疗中的价值。
该研究纳入了神经内科和耳鼻喉科收治的 50 例 BPPV 患者和 30 例无头晕病史的健康对照者。
BPPV 组和对照组在性别和年龄方面无统计学差异。BPPV 组的耳石蛋白-1 浓度明显高于对照组（710.44[584.35-837.39]比 280.45[212.7-419.61]； <0.001）。BPPV 组的 OC90 虽然高于对照组，但无统计学差异。BPPV 患者组中，耳石蛋白-1 与 OC90 呈强正相关，与维生素 D 呈中度负相关，OC90 与维生素 D 呈强负相关。耳石蛋白-1 对 BPPV 具有较高的特异性和 AUC 值（AUC：0.933；95%CI：0.881-0.986，79.2%的敏感性，100%的特异性，截断值大于 525）。
血清耳石蛋白-1 浓度升高与 BPPV 风险增加相关，而 OC90 浓度升高与 BPPV 无关。血清耳石蛋白-1 浓度可能可作为内耳疾病急性发作的生物标志物，因为 BPPV 患者的耳石蛋白-1 浓度显著增加。维生素 D 对 BPPV 患者具有较高的特异性和敏感性。这也为维生素 D 缺乏的 BPPV 患者通过替代疗法改善症状提供了证据。需要更多的大规模前瞻性研究来证实这些关联，并阐明确切的机制。
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