Singh Anup, Yadav Harsha, Verma Hitesh, Sikka Kapil, Abraham Ransi Ann, Irugu David Victor Kumar
Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
Department of Cardiac Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Int Arch Otorhinolaryngol. 2023 Aug 4;27(3):e440-e444. doi: 10.1055/s-0042-1749390. eCollection 2023 Jul.
Degenerative changes in the otolithic organs have been theorized to be caused by the mechanical obstruction to endolymphatic flow, possibly resulting in endolymphatic hydrops (ELH). Otolin-1 is an otoconial matrix protein that crosses the blood labyrinth barrier and has been found in the serum of healthy and diseased patients. To measure the serum levels of Otolin-1 in Meniere disease (MD) patients and compared them with the healthy individuals. This pilot, cross-sectional study was performed at our tertiary care referral center to compare the serum Otolin-1 levels of healthy individuals with those of MD patients. The blood samples were obtained during patients' visit to the vertigo clinic following remission of an acute episode. The data was analyzed using the Stata/SE version 12.0 (StataCorp. College Station, TX, USA). Comparison between the serum Otolin-1 levels in the two groups was performed using the unpaired -test. A -value of 0.05 was considered to be statistically significant. The participants were divided into two groups, with 31 MD patients, and 30 age and gender-matched members of the control group. The serum levels of Otolin-1 in MD patients (247.6, ± 44.2 pg/ml) were not found to be significantly different from those of the control group (236.2, ± 43.5 pg/ml) ( = 0.31). The current study reveals that the serum levels of Otolin-1 are not significantly different between the patients with MD in the interictal phase and the control group's healthy ones.
耳石器官的退行性变化被认为是由内淋巴流动的机械性阻塞引起的，这可能导致内淋巴积水（ELH）。Otolin-1是一种耳石基质蛋白，可穿过血迷路屏障，在健康和患病患者的血清中均有发现。
为了测量梅尼埃病（MD）患者血清中Otolin-1的水平，并将其与健康个体进行比较。
这项前瞻性横断面研究在我们的三级医疗转诊中心进行，以比较健康个体和MD患者的血清Otolin-1水平。在急性发作缓解后，患者到眩晕门诊就诊时采集血样。数据使用Stata/SE 12.0版本（美国德克萨斯州大学站StataCorp公司）进行分析。两组血清Otolin-1水平的比较采用非配对t检验。P值<0.05被认为具有统计学意义。
参与者分为两组，31例MD患者，以及30例年龄和性别匹配的对照组成员。MD患者血清Otolin-1水平（247.6±44.2 pg/ml）与对照组（236.2±43.5 pg/ml）相比无显著差异（P=0.31）。
目前的研究表明，发作间期MD患者与对照组健康个体的血清Otolin-1水平无显著差异。
