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2×4固定正畸治疗在混合牙列期的有效性及临床适应症：一项系统评价

Effectiveness and Clinical Indications of 2 × 4 Fixed Orthodontic Therapy in Regard to Mixed Dentition: A Systematic Review.

作者信息

Dipalma Gianna, Marinelli Grazia, Casamassima Lucia, Nardelli Paola, Ciccarese Danilo, Sena Paolo De, Inchingolo Francesco, Crincoli Vito, Palermo Andrea, Bordea Ioana Roxana, Carbonara Andrea, Inchingolo Angelo Michele, Inchingolo Alessio Danilo

机构信息

Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.

Department of Experimental Medicine, University of Salento, 73100 Lecce, Italy.

出版信息

Children (Basel). 2025 Jul 7;12(7):897. doi: 10.3390/children12070897.

DOI:10.3390/children12070897
PMID:40723090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12293636/
Abstract

BACKGROUND/OBJECTIVES: This systematic review examines the effectiveness and clinical indications of the 2 × 4 fixed orthodontic appliance for interceptive treatment in children with mixed dentition, aiming to simplify future orthodontic needs.

METHODS

Following the PRISMA guidelines, a search was conducted across PubMed, Web of Science, and Scopus (May 2000-May 2025). The inclusion criteria focused on open-access, in vivo/human studies, case-control studies, cohort studies, and RCTs in English. Risk of bias was assessed using Rob 2.0.

RESULTS

Out of 362 initial records, 7 studies were included. Most of the included studies showed a low risk of bias, with some moderate risk in terms of confounding variables and participant selection, but no high risk was identified.

CONCLUSIONS

The 2 × 4 fixed orthodontic appliance is an effective interceptive therapy for mixed dentition. Clinicians can optimize outcomes by understanding its biomechanics and clinical applications. Further research is needed to understand long-term impacts and improve efficiency.

摘要

背景/目的：本系统评价旨在探讨2×4固定正畸矫治器对混合牙列期儿童进行阻断性治疗的有效性和临床适应证，以期简化未来的正畸需求。

方法

按照PRISMA指南，在PubMed、Web of Science和Scopus数据库（2000年5月至2025年5月）进行检索。纳入标准集中于开放获取的、体内/人体研究、病例对照研究、队列研究以及英文的随机对照试验。采用Rob 2.0评估偏倚风险。

结果

在362条初始记录中，纳入了7项研究。大多数纳入研究显示偏倚风险较低，在混杂变量和参与者选择方面存在一些中度风险，但未发现高风险。

结论

2×4固定正畸矫治器是一种有效的混合牙列阻断性治疗方法。临床医生可通过了解其生物力学和临床应用来优化治疗效果。需要进一步研究以了解其长期影响并提高效率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79d/12293636/17bcb001b4ed/children-12-00897-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79d/12293636/ef70be839e4e/children-12-00897-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79d/12293636/7e34b2c4004e/children-12-00897-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79d/12293636/17bcb001b4ed/children-12-00897-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79d/12293636/ef70be839e4e/children-12-00897-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79d/12293636/7e34b2c4004e/children-12-00897-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79d/12293636/17bcb001b4ed/children-12-00897-g003.jpg

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Effectiveness and Clinical Indications of 2 × 4 Fixed Orthodontic Therapy in Regard to Mixed Dentition: A Systematic Review.2×4固定正畸治疗在混合牙列期的有效性及临床适应症：一项系统评价
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Paediatric dental trauma: insights from epidemiological studies and management recommendations.儿童牙外伤：来自流行病学研究的见解及管理建议
BMC Oral Health. 2025 Jan 2;25(1):6. doi: 10.1186/s12903-024-05222-5.
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The Effectiveness of Curcumin in Treating Oral Mucositis Related to Radiation and Chemotherapy: A Systematic Review.姜黄素治疗放疗和化疗相关口腔黏膜炎的有效性：一项系统评价
Antioxidants (Basel). 2024 Sep 25;13(10):1160. doi: 10.3390/antiox13101160.
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Prevalence of temporomandibular disorders in clear aligner patients using orthodontic intermaxillary elastics assessed with diagnostic criteria for temporomandibular disorders (DC/TMD) axis II evaluation: A cross-sectional study.使用正畸颌间弹力牵引的透明矫治器患者颞下颌关节紊乱病的患病率：采用颞下颌关节紊乱病诊断标准（DC/TMD）轴II评估的横断面研究。
J Oral Rehabil. 2024 Mar;51(3):500-509. doi: 10.1111/joor.13614. Epub 2023 Dec 2.
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Treatment Approaches to Molar Incisor Hypomineralization: A Systematic Review.磨牙切牙矿化不全的治疗方法：一项系统评价
J Clin Med. 2023 Nov 20;12(22):7194. doi: 10.3390/jcm12227194.
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Occurrence of Temporomandibular Disorders among patients undergoing treatment for Obstructive Sleep Apnoea Syndrome (OSAS) using Mandibular Advancement Device (MAD): A Systematic Review conducted according to PRISMA guidelines and the Cochrane handbook for systematic reviews of interventions.使用下颌前伸装置（MAD）治疗阻塞性睡眠呼吸暂停综合征（OSAS）患者中颞下颌关节紊乱病的发生：一项根据 PRISMA 指南和 Cochrane 干预系统评价手册进行的系统评价。
J Oral Rehabil. 2023 Dec;50(12):1554-1563. doi: 10.1111/joor.13574. Epub 2023 Aug 30.
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