Kassis A I, Harris C R, Adelstein S J, Ruth T J, Lambrecht R, Wolf A P
Radiat Res. 1986 Jan;105(1):27-36.
Chinese hamster V79 cells in culture were exposed to astatine-211, an alpha-particle-emitting radiohalogen. The dose-log survival response was linear with no detectable shoulder. Cells in monolayers had a D0 of 1.0 microCi/ml. Suspended cells had a D0 of 0.60 microCi/ml with a cellular uptake of 2.5 fCi/cell; this is equal to approximately 1.5 alpha-particle traversals per cell nucleus. The frequencies of chromosome and chromatid breaks were linear with dose, but the number declined rapidly with time. These data are discussed in relation to published alpha-particle beam studies and the potential use of 211At in radionuclide therapy.
将培养的中国仓鼠V79细胞暴露于砹-211（一种发射α粒子的放射性卤素）。剂量-存活对数响应呈线性，无明显的坪区。单层细胞的D0为1.0微居里/毫升。悬浮细胞的D0为0.60微居里/毫升，细胞摄取量为2.5微微居里/细胞；这相当于每个细胞核约有1.5次α粒子穿过。染色体和染色单体断裂的频率与剂量呈线性关系，但数量随时间迅速下降。结合已发表的α粒子束研究以及211At在放射性核素治疗中的潜在应用对这些数据进行了讨论。
