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使用 Hidecan R 包进行全基因组关联研究和差异表达结果的可视化整合。

Visual Integration of Genome-Wide Association Studies and Differential Expression Results with the Hidecan R Package.

机构信息

The New Zealand Institute for Plant and Food Research Limited, Palmerston North 4442, New Zealand.

School of Mathematical and Computational Sciences, Massey University, Palmerston North 4442, New Zealand.

出版信息

Genes (Basel). 2024 Sep 25;15(10):1244. doi: 10.3390/genes15101244.

DOI:10.3390/genes15101244
PMID:39457368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11506992/
Abstract

BACKGROUND/OBJECTIVES: We present hidecan, an R package for generating visualisations that summarise the results of one or more genome-wide association studies (GWAS) and differential expression analyses, as well as manually curated candidate genes, e.g., extracted from the literature. This tool is applicable to all ploidy levels; we notably provide functionalities to facilitate the visualisation of GWAS results obtained for autotetraploid organisms with the GWASpoly package.

RESULTS

We illustrate the capabilities of hidecan with examples from two autotetraploid potato datasets.

CONCLUSIONS

The hidecan package is implemented in R and is publicly available on the CRAN repository and on GitHub. A description of the package, as well as a detailed tutorial, is made available alongside the package. It is also part of the VIEWpoly tool for the visualisation and exploration of results from polyploids computational tools.

摘要

背景/目的:我们介绍了 hidecan,这是一个 R 包,用于生成可视化结果,总结一个或多个全基因组关联研究(GWAS)和差异表达分析的结果,以及手动整理的候选基因,例如从文献中提取的候选基因。该工具适用于所有倍性水平;我们特别提供了功能,以方便使用 GWASpoly 包可视化获得的同源四倍体生物的 GWAS 结果。

结果

我们用来自两个同源四倍体马铃薯数据集的示例来说明 hidecan 的功能。

结论

hidecan 包是用 R 实现的,在 CRAN 存储库和 GitHub 上都可以公开使用。该包的说明以及详细的教程也随包一起提供。它也是 VIEWpoly 工具的一部分,用于可视化和探索多倍体计算工具的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e13/11506992/f288dfc816fa/genes-15-01244-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e13/11506992/c5ec94ec60aa/genes-15-01244-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e13/11506992/2e0ef42a7dee/genes-15-01244-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e13/11506992/f288dfc816fa/genes-15-01244-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e13/11506992/c5ec94ec60aa/genes-15-01244-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e13/11506992/2e0ef42a7dee/genes-15-01244-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e13/11506992/f288dfc816fa/genes-15-01244-g003.jpg

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本文引用的文献

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