Department of Health Technology and Informatics, Faculty of Health and Social Science, The Hong Kong Polytechnic University, Hunghom, Hong Kong, China.
Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA.
Genes (Basel). 2024 Sep 26;15(10):1257. doi: 10.3390/genes15101257.
: Colorectal cancer (CRC) is the third most diagnosed cancer globally. Radiotherapy is a common treatment strategy for patients but factors such as gene expressions and molecular mechanism effects may affect tumor radioresponse. The aim of this review is to systematically identify genes suggested to have molecular mechanism effects on the radioresponsiveness of CRC patients. : By following the PRISMA guidelines, a comprehensive literature search was conducted on Pubmed, EMBASE and Cochrane Library. After exclusion and inclusion criteria sorting and critical appraisal for study quality, data were extracted from seven studies. A gene set analysis was conducted on reported genes. : From the seven studies, 56 genes were found to have an effect on CRC radioresponsiveness. Gene set analysis show that out of these 56 genes, 24 genes have roles in pathways which could affect cancer radioresponse. These are , , , , , , , , , , , , , , , , , , , , , , and . The current project was conducted between the period May 2024 to August 2024. : The current review systematically presented 56 genes which have been reported to be related to RT or CRT treatment effectiveness in rectal cancer patients. Gene set analysis shows that nearly half of the genes were involved in apoptosis, DNA damage response and repair, inflammation and cancer metabolism molecular pathways that could affect cancer radioresponse. The gene cohort identified in this study may be used as a foundation for future works focusing on the molecular mechanism of specific pathways contributing to the radioresponse of CRC.
: 结直肠癌（CRC）是全球第三大常见癌症。放射治疗是患者常用的治疗策略，但基因表达和分子机制等因素可能会影响肿瘤的放射反应。本综述旨在系统地确定那些被认为对 CRC 患者放射反应具有分子机制影响的基因。: 按照 PRISMA 指南，对 Pubmed、EMBASE 和 Cochrane Library 进行了全面的文献检索。在排除和纳入标准排序以及对研究质量进行批判性评价后，从 7 项研究中提取数据。对报告的基因进行了基因集分析。: 从这 7 项研究中，发现了 56 个对 CRC 放射反应有影响的基因。基因集分析显示，在这 56 个基因中，有 24 个基因在可能影响癌症放射反应的途径中发挥作用。这些是、、、、、、、、、、、、、、、、、、、、、、和。本项目于 2024 年 5 月至 2024 年 8 月进行。: 本综述系统地介绍了 56 个被报道与直肠癌患者 RT 或 CRT 治疗效果相关的基因。基因集分析表明，近一半的基因参与了细胞凋亡、DNA 损伤反应和修复、炎症和癌症代谢等分子途径，这些途径可能影响癌症的放射反应。本研究中确定的基因组可能作为未来专注于特定途径的分子机制研究的基础，这些途径有助于 CRC 的放射反应。
