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冠状动脉疾病患者中心脏非晶形左心室肿瘤的特点——诊断与治疗挑战:一例病例报告及文献综述

Particularities of a Cardiac Amorphous Left Ventricular Tumor in a Patient with Coronary Artery Disease-Diagnostic and Therapeutic Challenges: A Case Report and Literature Review.

作者信息

Streian Caius Glad, Tudoran Cristina, Staicu Raluca Elisabeta, Negru Alina Gabriela, Mederle Alexandra Laura, Borza Claudia, Lascu Ana

机构信息

Department VI Cardiology-Cardiovascular Surgery, "Victor Babeș" University of Medicine and Pharmacy of Timișoara, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.

Institute for Cardiovascular Diseases of Timisoara, "Victor Babeș" University of Medicine and Pharmacy of Timișoara, G. Adam Str. No. 13A, 300310 Timisoara, Romania.

出版信息

J Clin Med. 2024 Oct 12;13(20):6092. doi: 10.3390/jcm13206092.

Abstract

: Cardiac calcified amorphous tumors (CATs) are rare non-neoplastic formations containing amorphous fibrinous material and calcifications. In our research, we present the case of a 42-year-old male patient who developed, during his 6-months monitoring for coronary artery disease, a left ventricular (LV) CAT raising diagnostic challenges. : To gather additional information on CATs, we researched the international medical literature for scientific articles published with the full text in English, on PubMed, ResearchGate, Clarivate, and Google Scholar between 2020 and 2024. : Compared to most described cases, our patient was a young male, without mitral annular calcification or chronic renal disease, but he was suffering from chronic peripheral and coronary artery disease, and genetic testing revealed a higher risk for thromboembolic events. During 6 months, he developed a LV CAT of 4.5/3.5/3 cm. Although we found in the medical literature 16 case reports of patients with CAT, only six authors could specify a precise postoperative evolution of the CAT, most of them sustaining that if completely removed, it would not relapse, an aspect observed also in our patient during 3 years of follow-up. : CATs are rare heart tumors with slow growth, but with a high embolization risk that raises diagnostic and therapeutic challenges.

摘要

心脏钙化无定形肿瘤(CATs)是一种罕见的非肿瘤性病变,含有无定形纤维蛋白物质和钙化。在我们的研究中,我们报告了一例42岁男性患者的病例,该患者在接受冠状动脉疾病6个月的监测期间,出现了左心室CAT,这给诊断带来了挑战。

为了收集有关CATs的更多信息,我们在PubMed、ResearchGate、Clarivate和Google Scholar上检索了2020年至2024年间以英文全文发表的科学文章,以研究国际医学文献。

与大多数已描述的病例相比,我们的患者是一名年轻男性,没有二尖瓣环钙化或慢性肾病,但患有慢性外周和冠状动脉疾病,基因检测显示血栓栓塞事件的风险较高。在6个月内,他出现了一个大小为4.5/3.5/3厘米的左心室CAT。尽管我们在医学文献中发现了16例CAT患者的病例报告,但只有6位作者能够明确说明CAT术后的确切演变情况,他们中的大多数人认为,如果完全切除,CAT不会复发,我们的患者在3年的随访中也观察到了这一情况。

CATs是一种罕见的心脏肿瘤,生长缓慢,但栓塞风险高,给诊断和治疗带来挑战。

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