Wang Linqi, Wang Qinyu, Zhou Yan
State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China.
Microorganisms. 2024 Oct 18;12(10):2086. doi: 10.3390/microorganisms12102086.
Along with affecting oral health, oral microbial communities may also be endogenously translocated to the gut, thereby mediating the development of a range of malignancies in that habitat. While species-level studies have proven the capability of oral pathogens to migrate to the intestine, genetic evidence supporting this mechanism remains insufficient. In this study, we identified over 55,000 oral translocation genes (OTGs) associated with colorectal cancer (CRC) and inflammatory bowel disease (IBD). These genes are primarily involved in signal transduction and cell wall biosynthesis and show consistency in their functions between IBD and CRC. Furthermore, we found that , a newly discovered opportunistic pathogen, has a significantly high abundance in the gut microbiota of colorectal cancer patients. OTGs of this pathogen were enriched in 15 metabolic pathways, including those associated with amino acid and cofactor metabolism. These findings, for the first time, provide evidence at the genetic level of the transfer of oral pathogens to the intestine and offer new insights into the understanding of the roles of oral pathogens in the development of gastrointestinal cancers.
除了影响口腔健康外，口腔微生物群落也可能通过内源性途径转移至肠道，从而介导该部位一系列恶性肿瘤的发生发展。虽然物种水平的研究已经证实口腔病原体具有迁移至肠道的能力，但支持这一机制的遗传学证据仍然不足。在本研究中，我们鉴定出了超过55000个与结直肠癌（CRC）和炎症性肠病（IBD）相关的口腔易位基因（OTG）。这些基因主要参与信号转导和细胞壁生物合成，并且在IBD和CRC之间表现出功能上的一致性。此外，我们发现，一种新发现的机会性病原体，在结直肠癌患者的肠道微生物群中具有显著高丰度。该病原体的OTG在15种代谢途径中富集，包括与氨基酸和辅因子代谢相关的途径。这些发现首次在基因水平上为口腔病原体向肠道的转移提供了证据，并为理解口腔病原体在胃肠道癌症发生发展中的作用提供了新的见解。
