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与天然类黄酮/生物碱和 B/B 族维生素联合使用，可以改善炎症性肠病组织的炎症负担：一项 研究。

, in combination with natural flavonoid/alkaloid and B/B vitamins, can improve inflammatory burden in Inflammatory bowel diseases tissue: an study.

机构信息

Hepatogastroenterology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

Division of Internal Medicine and Gastroenterology, Cristo Re Hospital, Rome, Italy.

出版信息

Front Immunol. 2023 Jul 3;14:1215329. doi: 10.3389/fimmu.2023.1215329. eCollection 2023.

DOI:10.3389/fimmu.2023.1215329
PMID:37465689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10350490/
Abstract

, berberine, and quercetin are effective in experimental colitis. It is unknown whether they can ameliorate inflammatory bowel diseases in humans. This study aimed to evaluate the anti-inflammatory potential of a nutraceutical compound of HBQ-Complex (, berberine, and quercetin), biotin, and niacin in inflammatory bowel disease patients. Tissue specimens were obtained either from Normal-Appearing Mucosa (NAM) or from Inflamed Mucosa (IM) in 20 patients with inflammatory bowel disease. mRNA and protein expression of COX-2, IL-10, and TNF-α were determined in NAM and IM biopsy samples (T0). IM samples were then incubated in HBQ-Complex (with the addition of niacin and biotin), and COX-2, IL-10, and TNF-α tissue levels were evaluated at 120 minutes (T1) and 180 minutes (T2). Incubation with this compound resulted in a progressive decrease in gene and protein COX-2 and TNF-α expression at T1/T2 in the IM. IL-10 showed an opposite trend, with a progressive increase of mRNA and protein expression over the same time window. HBQ-Complex (with the addition of niacin and biotin) decreased the expression of proinflammatory cytokines at the mRNA and protein levels in IBD tissue. On the contrary, mRNA and protein expression of the anti-inflammatory cytokine IL-10 showed a progressive increase.

摘要

小檗碱、槲皮素和姜黄素在实验性结肠炎中有效。它们是否能改善人类的炎症性肠病尚不清楚。本研究旨在评估 HBQ-Complex（小檗碱、槲皮素和姜黄素）、生物素和烟酸的一种营养复合物在炎症性肠病患者中的抗炎潜力。从 20 例炎症性肠病患者的正常外观黏膜（NAM）或炎症黏膜（IM）中获取组织标本。在 NAM 和 IM 活检样本（T0）中测定 COX-2、IL-10 和 TNF-α的 mRNA 和蛋白表达。然后将 IM 样本在 HBQ-Complex（加入烟酸和生物素）中孵育，并在 120 分钟（T1）和 180 分钟（T2）时评估 COX-2、IL-10 和 TNF-α的组织水平。在 T1/T2 时，该化合物的孵育导致 IM 中 COX-2 和 TNF-α基因和蛋白表达逐渐降低。IL-10 表现出相反的趋势，在相同的时间窗口内，mRNA 和蛋白表达逐渐增加。在 IBD 组织中，HBQ-Complex（加入烟酸和生物素）降低了促炎细胞因子的 mRNA 和蛋白水平表达。相反，抗炎细胞因子 IL-10 的 mRNA 和蛋白表达逐渐增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b40/10350490/2e5f8771fe18/fimmu-14-1215329-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b40/10350490/d4e3196c9b44/fimmu-14-1215329-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b40/10350490/6bc6b8912d33/fimmu-14-1215329-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b40/10350490/28772a66f756/fimmu-14-1215329-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b40/10350490/e5b4e78c3c77/fimmu-14-1215329-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b40/10350490/2e5f8771fe18/fimmu-14-1215329-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b40/10350490/d4e3196c9b44/fimmu-14-1215329-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b40/10350490/6bc6b8912d33/fimmu-14-1215329-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b40/10350490/28772a66f756/fimmu-14-1215329-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b40/10350490/e5b4e78c3c77/fimmu-14-1215329-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b40/10350490/2e5f8771fe18/fimmu-14-1215329-g005.jpg

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