Graduate School of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.
Research Fellow of Japan Society for the Promotion of Science, Tokyo 102-0083, Japan.
Nutrients. 2024 Oct 19;16(20):3546. doi: 10.3390/nu16203546.
The human gut environment undergoes substantial changes as a host ages. This investigation centered on the gut microbiome diversity among patients with severe motor and intellectual disabilities (SMID), examining the association between the gut microbiome composition and physical characteristics with varying levels of diversity.
Fourteen subjects were investigated, with physical and defecation status, blood biochemical test, gut microbiome profiling, and fecal metabolites used to divide the patients into a high-diversity group (HD, eight patients) and a low-diversity group (LD, six patients).
Findings indicated that the microbiome of the LD group showed delayed maturation reminiscent of neonates and lactating infants. Analysis of the fecal bile acids (BAs) revealed a markedly diminished proportion of deoxycholic acid in the secondary BAs in the LD group, suggestive of inadequate conversion from primary to secondary BAs. Furthermore, the LD group presented with loose stools. The LD group exhibited a higher degree of physical severity, with all patients bedridden and fed via gastrostomy with only enteral formula received.
The composition of the gut microbiome and BAs in the LD group was found to differ from those of healthy individuals and the HD group, indicating a potentially immature gut environment for these individuals.
随着宿主年龄的增长，人体肠道环境会发生重大变化。本研究集中于严重运动和智力障碍（SMID）患者的肠道微生物组多样性，考察了肠道微生物组组成与物理特征之间的关联，以及不同多样性水平之间的关联。
对 14 名受试者进行了调查，通过身体和排便状况、血液生化试验、肠道微生物组分析以及粪便代谢物，将患者分为高多样性组（HD，8 名患者）和低多样性组（LD，6 名患者）。
研究结果表明，LD 组的微生物组表现出类似于新生儿和哺乳期婴儿的延迟成熟。粪便胆汁酸（BAs）分析显示，LD 组次级 BAs 中的脱氧胆酸比例明显减少，提示从初级到次级 BAs 的转化不足。此外，LD 组的粪便呈松散状。LD 组表现出更高程度的身体严重程度，所有患者卧床不起，通过胃造口术喂食，仅接受肠内配方。
LD 组肠道微生物组和 BAs 的组成与健康个体和 HD 组不同，表明这些个体的肠道环境可能不成熟。
