镜像 RNA：一种右手 Z 型 RNA 及其配体复合物。

Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.

Molecules. 2024 Oct 16;29(20):4900. doi: 10.3390/molecules29204900.

Until now, Z-form RNAs were believed to only adopt a left-handed double-helix structure. In this study, we describe the first observation of a right-handed Z-form RNA in NMR solution formed by L-nucleic acid RNA and present the first resolution of structure of the complex between a right-handed Z-form RNA and a curaxin ligand. These results provide a platform for the design of topology specific to Z-form-targeting compounds and are valuable for the development of new potent anticancer drugs.

到目前为止，Z 型 RNA 被认为只采用左手双螺旋结构。在这项研究中，我们描述了在 NMR 溶液中首次观察到 L-核酸 RNA 形成的右手 Z 型 RNA，并首次解析了右手 Z 型 RNA 与 curaxin 配体之间复合物的结构。这些结果为设计针对 Z 型的拓扑特异性化合物提供了平台，对于开发新型有效的抗癌药物具有重要价值。