Morgan K T, Jiang X Z, Starr T B, Kerns W D
Toxicol Appl Pharmacol. 1986 Feb;82(2):264-71. doi: 10.1016/0041-008x(86)90201-2.
Considerable interest and research have resulted from the finding that squamous cell carcinomas, polypoid adenomas, and a small number of other nasal neoplasms occurred in F-344 rats following chronic inhalation exposure to formaldehyde. These tumors were reported to originate in the anterior portion of the nasal cavity but their precise location in the nose was not determined. Histologic sections from the nasal passages of these rats have been reexamined and the location of each tumor has been recorded. The majority of squamous cell carcinomas occurred on the anterior portion of the lateral aspect of the nasoturbinate and adjacent lateral wall (57%) or the midventral nasal septum (26%). Polypoid adenomas were confined to a small region of the anterior nasal cavity and were restricted to the free margins of the naso-and maxilloturbinates and lateral wall adjacent to these margins. One neoplasm, considered to be the malignant counterpart of the polypoid adenoma, originated on the dorsal margin of the maxilloturbinate in the same region of the nose. Remaining neoplasms were generally too large or too poorly preserved for assessment of their site of origin. Mechanistic studies directed toward a better understanding of the nasal carcinogenicity of formaldehyde, or other nasal carcinogens. should take into account the anatomic sites of origin of the neoplasms whenever this can be determined.
长期吸入甲醛后，F-344大鼠出现了鳞状细胞癌、息肉状腺瘤以及少数其他鼻腔肿瘤，这一发现引发了广泛关注和研究。据报道，这些肿瘤起源于鼻腔前部，但它们在鼻腔中的精确位置尚未确定。对这些大鼠鼻腔通道的组织切片进行了重新检查，并记录了每个肿瘤的位置。大多数鳞状细胞癌发生在鼻甲骨外侧前部及相邻的侧壁（57%）或鼻中隔腹侧中部（26%）。息肉状腺瘤局限于鼻腔前部的一个小区域，仅限于鼻甲骨和上颌甲骨的游离边缘以及邻近这些边缘的侧壁。一种被认为是息肉状腺瘤恶性对应物的肿瘤，起源于鼻腔同一区域上颌甲骨的背侧边缘。其余肿瘤通常过大或保存不佳，无法评估其起源部位。对于旨在更好地理解甲醛或其他鼻腔致癌物鼻腔致癌性的机制研究，只要能够确定，就应考虑肿瘤的解剖起源部位。
