在相隔 12 天的两个连续样本中首次检测并描述人类阴道中的 。
First Detection and Characterization of in the Human Vagina in Two Sequential Samples over a Twelve-Day Interval.
机构信息
Laboratorio de Virologia (LIM52), Departamento de Infectologia e Medicina Tropical, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina da Universidade de São Paulo, Av. Dr Enéas de Carvalho Aguiar, 470, São Paulo 05403-000, Brazil.
Laboratório de Diversidade Viral, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-110, Brazil.
出版信息
Viruses. 2024 Sep 30;16(10):1545. doi: 10.3390/v16101545.
BACKGROUND
is a CRESS-DNA virus identified almost exclusively in transient fecal samples from various vertebrate species.
OBJECTIVE
We evaluated human vaginal samples for the presence and maintenance of .
METHODS
Viral metagenomics analysis was performed on vaginal samples collected from 28 apparently healthy women in New York City, USA. Twenty-one of the women provided duplicate samples over a 12-21-day interval.
RESULTS
Phylogenetic analysis identified two samples from the same individual, collected over a twelve-day interval, that were positive for the complete genome. All detected sequence contigs belonged to a single variant of CRESS-DNA.
CONCLUSIONS
The continuous presence of in the human vagina over a twelve-day period was identified.
背景
是一种 CRESS-DNA 病毒，几乎只存在于各种脊椎动物的一过性粪便样本中。
目的
我们评估了人类阴道样本中 的存在和维持情况。
方法
对来自美国纽约市 28 名看似健康的女性的阴道样本进行了病毒宏基因组分析。其中 21 名女性在 12-21 天的时间间隔内提供了重复样本。
结果
系统发育分析鉴定出来自同一女性的两个样本，在 12 天的间隔内均为 基因组完整阳性。所有检测到的序列连续簇都属于 CRESS-DNA 的单一变体。
结论
确定了 在人类阴道中持续存在 12 天。
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