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采用双收尾晶体方法提高脑成像双端 PET 探测器的定时性能。

Enhanced Timing Performance of Dual-Ended PET Detectors for Brain Imaging Using Dual-Finishing Crystal Approach.

机构信息

Brightonix Imaging Inc., Seoul 04782, Republic of Korea.

出版信息

Sensors (Basel). 2024 Oct 10;24(20):6520. doi: 10.3390/s24206520.

DOI:10.3390/s24206520
PMID:39460003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11511292/
Abstract

This study presents a novel approach to enhancing the timing performance of dual-ended positron emission tomography (PET) detectors for brain imaging by employing a dual-finishing crystal method. The proposed method integrates both polished and unpolished surfaces within the scintillation crystal block to optimize time-of-flight (TOF) and depth-of-interaction (DOI) resolutions. A dual-finishing detector was constructed using an 8 × 8 LGSO array with a 2 mm pitch, and its performance was compared against fully polished and unpolished crystal blocks. The results indicate that the dual-finishing method significantly improves the timing resolution while maintaining good energy and DOI resolutions. Specifically, the timing resolution achieved with the dual-finishing block was superior, measuring 192.0 ± 12.8 ps, compared to 206.3 ± 9.4 ps and 234.8 ± 17.9 ps for polished and unpolished blocks, respectively. This improvement in timing is crucial for high-performance PET systems, particularly in brain imaging applications where high sensitivity and spatial resolution are paramount.

摘要

本研究提出了一种新颖的方法,通过采用双精加工晶体方法来提高用于脑成像的双端正电子发射断层扫描(PET)探测器的定时性能。该方法在闪烁晶体块内集成了抛光和未抛光表面,以优化飞行时间(TOF)和相互作用深度(DOI)分辨率。使用具有 2 毫米间距的 8×8LGSO 阵列构建了一个双精加工探测器,并将其性能与完全抛光和未抛光晶体块进行了比较。结果表明,双精加工方法在保持良好的能量和 DOI 分辨率的同时,显著提高了定时分辨率。具体而言,双精加工块实现的定时分辨率为 192.0 ± 12.8 ps,优于抛光块的 206.3 ± 9.4 ps 和未抛光块的 234.8 ± 17.9 ps。这种定时性能的提高对于高性能 PET 系统至关重要,特别是在需要高灵敏度和空间分辨率的脑成像应用中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/4d3f81dfa9e2/sensors-24-06520-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/790ec4be44c0/sensors-24-06520-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/185b77ce3e3d/sensors-24-06520-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/55c39458237b/sensors-24-06520-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/53a7dfd6f724/sensors-24-06520-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/884c80c41402/sensors-24-06520-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/4d3f81dfa9e2/sensors-24-06520-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/790ec4be44c0/sensors-24-06520-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/647ee656dbe5/sensors-24-06520-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/d00008c646ef/sensors-24-06520-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/28eb7ba49625/sensors-24-06520-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/22c4d63d0c28/sensors-24-06520-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/185b77ce3e3d/sensors-24-06520-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/55c39458237b/sensors-24-06520-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/53a7dfd6f724/sensors-24-06520-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/884c80c41402/sensors-24-06520-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d57/11511292/4d3f81dfa9e2/sensors-24-06520-g010.jpg

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本文引用的文献

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Dual threshold input receiver FPGA-only signal digitization method for time-of-flight positron emission tomography.用于飞行时间正电子发射断层扫描的仅使用现场可编程门阵列的双阈值输入接收器信号数字化方法
Biomed Eng Lett. 2024 May 4;14(4):847-858. doi: 10.1007/s13534-024-00380-5. eCollection 2024 Jul.
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Performance Characteristics of the NeuroEXPLORER, a Next-Generation Human Brain PET/CT Imager.新一代人脑正电子发射断层显像/计算机断层扫描(PET/CT)成像仪NeuroEXPLORER的性能特征
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Pushing the limit of BGO-based dual-ended Cherenkov PET detectors through photon transit time correction.
通过光子渡越时间校正推动基于 BGO 的双端切伦科夫 PET 探测器的极限。
Phys Med Biol. 2024 Jan 5;69(2). doi: 10.1088/1361-6560/ad1549.
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