Kazeminejad Shervin, Arzhang Pishva, Baniasadi Mohammadreza Moradi, Hatami Alireza, Azadbakht Leila
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, 14155-6117, Iran.
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, 14155-6117, Iran.
Nutr Rev. 2025 Mar 1;83(3):405-421. doi: 10.1093/nutrit/nuae151.
Inconsistent results have been reported regarding the effects of different types of algae, such as Spirulina and Chlorella, on anthropometric indices.
To conduct a meta-analysis to assess the efficacy of algae supplementation on anthropometric indices.
A comprehensive systematic search was conducted to find relevant articles published from January 1990 to January 2024.
Randomized controlled trials (RCTs) comparing algae supplementation with a placebo or control group were included. The risk of bias and certainty of the evidence were evaluated using the Cochrane risk-of-bias tool and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, respectively. The random-effects model was used to find the Weighted mean differences (WMDs) for each outcome.
Of 9079 distinct articles in the initial screening, 61 clinical trials were included in this meta-analysis. Algae supplementation resulted in lower body mass index (WMD, -0.27 kg/m2 (95% CI, -0.42 to -0.13); GRADE rating, low), body weight (WMD: -0.78 kg [-1.18 to -0.38]; GRADE rating, low), waist circumference (WMD, -0.68 cm [-1.27 to -0.10]; GRADE rating, very low), kilograms of body fat (WMD, -0.65 kg [-1.13 to -0.17]; GRADE rating, low), and body fat percentage (WMD, -0.9% [-1.62 to -0.17]; GRADE rating, very low) compared with placebo or controls. Nevertheless, the statistically significant effects of algae supplementation on hip circumference (WMD, -0.20 cm [-0.73 to 0.32]; GRADE rating, moderate), waist to hip ratio (WMD, -0.01 [-0.01 to 0.00]; GRADE rating, moderate), and lean body mass (WMD, -0.30 kg [-0.62 to 0.02]; GRADE rating, moderate) were not observed.
Overall, the findings of this meta-analysis indicate supplementation with algae may exert beneficial effects on anthropometric indices. However, due to between-studies heterogeneity and very low to low levels of GRADE for significant outcomes, the results should be interpreted with caution.
PROSPERO registration no. CRD42024522923.
关于不同类型的藻类，如螺旋藻和小球藻，对人体测量指标的影响，已有不一致的研究结果报道。
进行一项荟萃分析，以评估补充藻类对人体测量指标的功效。
进行了全面的系统检索，以查找1990年1月至2024年1月发表的相关文章。
纳入比较补充藻类与安慰剂或对照组的随机对照试验（RCT）。分别使用Cochrane偏倚风险工具和推荐分级评估、制定与评价（GRADE）方法评估偏倚风险和证据的确定性。采用随机效应模型计算每个结局的加权平均差（WMD）。
在初始筛选的9079篇不同文章中，本荟萃分析纳入了61项临床试验。与安慰剂或对照组相比，补充藻类导致体重指数降低（WMD，-0.27kg/m²（95%CI，-0.42至-0.13）；GRADE分级，低）、体重降低（WMD：-0.78kg[-1.18至-0.38]；GRADE分级，低）、腰围降低（WMD，-0.68cm[-1.27至-0.10]；GRADE分级，极低）、体脂肪千克数降低（WMD，-0.65kg[-1.13至-0.17]；GRADE分级，低）和体脂百分比降低（WMD，-0.9%[-1.62至-0.17]；GRADE分级，极低）。然而，未观察到补充藻类对臀围（WMD，-0.20cm[-0.73至0.32]；GRADE分级，中等）、腰臀比（WMD，-0.01[-0.01至0.00]；GRADE分级，中等）和瘦体重（WMD，-0.30kg[-0.62至0.02]；GRADE分级，中等）有统计学显著影响。
总体而言，本荟萃分析的结果表明补充藻类可能对人体测量指标产生有益影响。然而，由于研究间的异质性以及显著结局的GRADE分级极低至低，结果应谨慎解释。
PROSPERO注册号CRD42024522923。
