Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Sci Rep. 2024 Oct 26;14(1):25559. doi: 10.1038/s41598-024-77335-4.
Oxidative stress plays a role in the pathophysiology of metabolic syndrome (MetS), and one of the most important features of polyphenols is their antioxidant properties. However, there is no universal consensus on the effectiveness of polyphenols in treating Mets. Therefore, the present study aimed to investigate the association between polyphenols and MetS in an Iranian sample. This cross-sectional study was conducted on an adult population sample from Shiraz, in southern Iran. MetS was calculated using the criteria of the Adult Treatment Panel III (ATP III), which defines MetS as the presence of three or more of the specified risk factors. A validated food frequency questionnaire (FFQ) was used to measure the participant's food intake. The association between polyphenol intake and the odds on MetS and its components was assessed using logistic regression. In both univariate and multivariate models, the association between polyphenol intake and the risk of MetS was not significant. However, after adjusting for potential confounders in the multivariate model, each unit change in flavonol, flavanone and isoflavones intake was associated with a lower, higher, and higher odds of MetS, respectively (flavonols: odds ratio (OR) = 0.926, 95% confidence interval (CI) 0.891-0.963, P < 0.001-flavanones: OR = 1.007, 95% CI: 1.001-1.014, P = 0.034-isoflavones: OR = 4.920, 95% CI: 1.057-22.894, P = 0.042). Additionally, no significant association was found between polyphenol intake and the risk of MetS components. However, in the multivariate model, after adjusting for potential confounders, a significant association was observed between polyphenol intake and lower odds of high waist circumference (OR = 0.998, 95% CI: 0.996-0.999, P = 0.032). The present study did not reveal a significant association between overall polyphenol intake and the odds of MetS. However, certain subclasses of polyphenols appear to be associated with the likelihood of MetS and its components.
氧化应激在代谢综合征（MetS）的病理生理学中起作用，而多酚最重要的特征之一是其抗氧化特性。然而，多酚在治疗 Mets 方面的有效性尚未达成普遍共识。因此，本研究旨在调查伊朗人群中多酚与 Mets 之间的关系。这项横断面研究在伊朗南部设拉子的成年人群样本中进行。MetS 是根据成人治疗小组 III（ATP III）的标准计算的，该标准将 Mets 定义为存在三种或更多指定的危险因素。使用经过验证的食物频率问卷（FFQ）来衡量参与者的食物摄入量。使用逻辑回归评估多酚摄入量与 Mets 及其成分的比值比（OR）之间的关联。在单变量和多变量模型中，多酚摄入量与 Mets 风险之间的关联均不显著。然而，在多变量模型中调整潜在混杂因素后，每单位黄酮醇、黄烷酮和异黄酮摄入量与 Mets 的风险呈负相关、正相关和正相关（黄酮醇：比值比（OR）= 0.926，95%置信区间（CI）0.891-0.963，P < 0.001-黄烷酮：OR = 1.007，95% CI：1.001-1.014，P = 0.034-异黄酮：OR = 4.920，95% CI：1.057-22.894，P = 0.042）。此外，多酚摄入量与 Mets 成分的风险之间也没有显著关联。然而，在多变量模型中，在调整潜在混杂因素后，多酚摄入量与较低的高腰围风险呈显著负相关（OR = 0.998，95% CI：0.996-0.999，P = 0.032）。本研究未发现总体多酚摄入量与 Mets 风险的比值比之间存在显著关联。然而，某些多酚亚类似乎与 Mets 及其成分的发生几率有关。
