Lanuza Fabian, Zamora-Ros Raul, Bondonno Nicola P, Meroño Tomas, Rostgaard-Hansen Agnetha Linn, Riccardi Gabriele, Tjønneland Anne, Landberg Rikard, Halkjær Jytte, Andres-Lacueva Cristina
Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Food Innovation Network (XIA), Nutrition and Food Safety Research Institute (INSA), Faculty of Pharmacy and Food Sciences, University of Barcelona (UB), 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, 28029, Spain.
Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Food Innovation Network (XIA), Nutrition and Food Safety Research Institute (INSA), Faculty of Pharmacy and Food Sciences, University of Barcelona (UB), 08028 Barcelona, Spain; Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Nutr Metab Cardiovasc Dis. 2023 Jun;33(6):1167-1178. doi: 10.1016/j.numecd.2023.02.022. Epub 2023 Mar 2.
Polyphenol-rich foods have beneficial properties that may lower cardiometabolic risk. We aimed to prospectively investigate the relationship between intakes of dietary polyphenols, and metabolic syndrome (MetS) and its components, in 676 Danish residents from the MAX study, a subcohort of the Danish Diet, Cancer and Health-Next Generations (DCH-NG) cohort.
Dietary data were collected using web-based 24-h dietary recalls over one year (at baseline, and at 6 and 12 months). The Phenol-Explorer database was used to estimate dietary polyphenol intake. Clinical variables were also collected at the same time point. Generalized linear mixed models were used to investigate relationships between polyphenol intake and MetS. Participants had a mean age of 43.9y, a mean total polyphenol intake of 1368 mg/day, and 75 (11.6%) had MetS at baseline. Compared to individuals with MetS in Q1 and after adjusting for age, sex, lifestyle and dietary confounders, those in Q4 - for total polyphenols, flavonoids and phenolic acids-had a 50% [OR (95% CI): 0.50 (0.27, 0.91)], 51% [0.49 (0.26, 0.91)] and 45% [0.55 (0.30, 1.00)] lower odds of MetS, respectively. Higher total polyphenols, flavonoids and phenolic acids intakes as continuous variable were associated with lower risk for elevated systolic blood pressure (SBP) and low high-density lipoprotein cholesterol (HDL-c) (p < 0.05).
Total polyphenol, flavonoid and phenolic acid intakes were associated with lower odds of MetS. These intakes were also consistently and significantly associated with a lower risk for higher SBP and lower HDL-c concentrations.
富含多酚的食物具有有益特性，可能降低心血管代谢风险。我们旨在对丹麦饮食、癌症与健康-下一代（DCH-NG）队列的一个亚组——MAX研究中的676名丹麦居民，前瞻性地研究膳食多酚摄入量与代谢综合征（MetS）及其组分之间的关系。
通过基于网络的24小时膳食回顾法收集一年（基线、6个月和12个月时）的膳食数据。使用酚类物质探索者数据库估算膳食多酚摄入量。同时收集临床变量。采用广义线性混合模型研究多酚摄入量与MetS之间的关系。参与者的平均年龄为43.9岁，总多酚平均摄入量为1368毫克/天，基线时75人（11.6%）患有MetS。与第一四分位数患有MetS的个体相比，在调整年龄、性别、生活方式和膳食混杂因素后，第四四分位数的个体——总多酚、黄酮类化合物和酚酸——患MetS的几率分别降低50% [比值比（95%置信区间）：0.50（0.27，0.91）]、51% [0.49（0.26，0.91）]和45% [0.55（0.30，1.00）]。总多酚、黄酮类化合物和酚酸摄入量作为连续变量，与收缩压升高（SBP）和高密度脂蛋白胆固醇（HDL-c）降低的风险较低相关（p < 0.05）。
总多酚、黄酮类化合物和酚酸摄入量与MetS几率较低相关。这些摄入量还始终且显著地与较高SBP和较低HDL-c浓度的较低风险相关。
