Department of Medical Data Intelligence, Research Center for Health-Medical Data Science, Graduate School of Medicine, Hirosaki University, Aomori, Japan.
Human Health Care Products Research Laboratories, Kao Corporation, Tokyo, Japan.
Sci Rep. 2024 Oct 26;14(1):25498. doi: 10.1038/s41598-024-76478-8.
The association between visceral fat area (VFA) and locomotive syndrome (LS) has been extensively studied in the older population; however, the association between VFA and early-stage LS (stage 1 [LS1]) remains unclear. In this cross-sectional study, we investigated this association across different age groups. The study involved 1,236 (524 male and 712 female) participants (aged 20-85 years). Multiple regression analysis adjusted for sex, body mass index, skeletal muscle mass index, T-score, exercise habits, smoking status, and alcohol consumption revealed a significant association between LS1 and VFA across all VFA quartiles. The adjusted odds ratio OR for quartiles 2, 3, and 4 was 1.84, 2.68, and 4.12, respectively. The association between LS1 and VFA across the age groups-high VFA (> 73 cm) and non-older (< 65 years) (OR, 1.87; 95% CI, 1.28-2.72; p = 0.001), low VFA (≤ 73 cm) and older (≥ 65 years) (OR, 3.16; 95% CI, 1.94-5.14; p < 0.001), and high VFA and older groups (OR, 6.43; 95% CI, 3.98-10.4; p < 0.001)-was significantly stronger than that in the low VFA and non-older group. In summary, our findings suggest that managing VFA through diet and exercise is crucial for preventing LS1 across all age groups.
内脏脂肪面积（VFA）与运动障碍综合征（LS）之间的关联在老年人群中已得到广泛研究；然而，VFA 与早期 LS（第 1 阶段[LS1]）之间的关联尚不清楚。在这项横断面研究中，我们调查了不同年龄组之间的这种关联。该研究涉及 1236 名（524 名男性和 712 名女性）参与者（年龄 20-85 岁）。多元回归分析调整了性别、体重指数、骨骼肌质量指数、T 评分、运动习惯、吸烟状况和饮酒量，结果显示 LS1 与所有 VFA 四分位数之间存在显著关联。第 2、3 和 4 四分位数的调整后比值比（OR）分别为 1.84、2.68 和 4.12。LS1 与 VFA 之间的关联在高 VFA（>73cm）和非老年（<65 岁）（OR，1.87；95%CI，1.28-2.72；p=0.001），低 VFA（≤73cm）和老年（≥65 岁）（OR，3.16；95%CI，1.94-5.14；p<0.001）和高 VFA 与老年组（OR，6.43；95%CI，3.98-10.4；p<0.001）之间的关联明显强于低 VFA 和非老年组。总之，我们的研究结果表明，通过饮食和运动来控制 VFA 对于预防所有年龄组的 LS1 至关重要。
