Departments of Sensory & Motor System Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Planning, Information and Management, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan.
BMC Geriatr. 2021 Nov 19;21(1):651. doi: 10.1186/s12877-021-02600-4.
Mobility decrease leading to disability can gradually develop during early life, however, its related factors are not well clarified. Therefore, we investigate the related factors of mobility decrease at various levels, using nationwide data in Japan.
In total, 8681 independent community dwellers aged 20-89 years were analysed (average age, 51.6 years; 58.5% women). Three stages of mobility decrease were based on the locomotive syndrome risk test: Stage 1, emerging; Stage 2, progressing; Stage 3, progressed to restrict social engagement. Age was analysed using a simple quadratic function model.
The prevalence of Stages 1-3 was 31.6% (n = 2746), 5.8% (n = 504), and 3.2% (n = 278), respectively. On the multivariable logistic regression, increased age in participants aged ≥40 years (stage 1: odds ratio[OR] 1.05-1.20, stage 2: OR 1.04-1.22, stage 3: OR 1.05-1.22), female (stage 1: OR 2.28, 95% confidence interval [CI] 1.99-2.61, stage 2: OR 2.40, 95% CI 1.77-3.25, stage 3: OR 1.80, 95% CI 1.19-2.72), overweight status (stage 1: OR 1.56, 95% CI 1.34-1.82, stage 2: OR 3.19, 95% CI 2.38-4.27, stage 3: OR 2.87, 95% CI 1.90-4.32), hypertension (stage 1: OR 1.20, 95% CI 1.01-1.41, stage 2: OR 1.99, 95% CI 1.49-2.64, stage 3: OR 2.10, 95% CI 1.44-3.05), and diabetes mellitus (stage 1: OR 1.62, 95% CI 1.17-2.24, stage 2: OR 1.57, 95% CI 0.93-2.66, stage 3: OR 2.10, 95% CI 1.13-3.90) were positively associated. The frequency of physical activity/sports, even a few per month, was inversely associated with all stages (stage 1: OR 0.59-0.72, stage 2: OR 0.50-0.67, stage 3: 0.36-0.53). A one-year increase in age had a stronger impact on mobility decrease in older adults than in younger ones. Increased age in participants aged < 40 years and smoking were associated with Stage 1, while intake of various foods was inversely associated with Stages 1 and 2.
Increased age (< 40 years) was associated with emerging mobility decrease, while that (≥ 40 years) was associated with any levels of mobility decrease. Female, lifestyle habits, including physical activities and overweight status, were associated with mobility decrease at every level.
行动能力下降导致残疾可能会在生命早期逐渐出现,但相关因素尚不清楚。因此,我们使用日本全国范围内的数据来研究各个水平的行动能力下降的相关因素。
共有 8681 名 20-89 岁的独立社区居民(平均年龄 51.6 岁;58.5%为女性)参与了本研究。根据运动障碍风险测试,将行动能力下降分为三个阶段:阶段 1,出现;阶段 2,进展;阶段 3,进展到限制社交参与。使用简单二次函数模型分析年龄。
三个阶段的患病率分别为 31.6%(n=2746)、5.8%(n=504)和 3.2%(n=278)。多变量逻辑回归分析显示,≥40 岁的参与者(阶段 1:比值比[OR]1.05-1.20,阶段 2:OR1.04-1.22,阶段 3:OR1.05-1.22)、女性(阶段 1:OR2.28,95%置信区间[CI]1.99-2.61,阶段 2:OR2.40,95%CI1.77-3.25,阶段 3:OR1.80,95%CI1.19-2.72)、超重状态(阶段 1:OR1.56,95%CI1.34-1.82,阶段 2:OR3.19,95%CI2.38-4.27,阶段 3:OR2.87,95%CI1.90-4.32)、高血压(阶段 1:OR1.20,95%CI1.01-1.41,阶段 2:OR1.99,95%CI1.49-2.64,阶段 3:OR2.10,95%CI1.44-3.05)和糖尿病(阶段 1:OR1.62,95%CI1.17-2.24,阶段 2:OR1.57,95%CI0.93-2.66,阶段 3:OR2.10,95%CI1.13-3.90)与所有阶段均呈正相关。即使每月进行几次体育活动/运动,与所有阶段均呈负相关(阶段 1:OR0.59-0.72,阶段 2:OR0.50-0.67,阶段 3:0.36-0.53)。与年轻人相比,年龄的增加对老年人的行动能力下降影响更大。年龄<40 岁的参与者年龄增加与第 1 阶段相关,而各种食物的摄入与第 1 阶段和第 2 阶段呈负相关。
年龄增加(<40 岁)与早期行动能力下降相关,而年龄增加(≥40 岁)与任何水平的行动能力下降相关。女性、包括体育活动在内的生活方式习惯和超重状态与各个水平的行动能力下降相关。