一项针对老年女性癌症患者的虚拟同伴支持锻炼干预的初步随机对照试验。

A pilot randomized controlled trial of a virtual peer-support exercise intervention for female older adults with cancer.

机构信息

School of Rehabilitation Science, McMaster University, 1400 Main Street West, Hamilton, ON, L8S 1C7, Canada.

Faculty of Kinesiology and Physical Education, University of Toronto, 55 Harbord Street, Toronto, ON, M5S 2W6, Canada.

出版信息

BMC Geriatr. 2024 Oct 26;24(1):887. doi: 10.1186/s12877-024-05495-z.

DOI:10.1186/s12877-024-05495-z

PMID:39462335

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11515269/

Abstract

BACKGROUND

Regular exercise can mitigate side effects of cancer treatment. However, only a small proportion of adults with cancer meet exercise guidelines, and older adults (> 65 years) are underrepresented in cancer rehabilitation research. Peer support facilitates health-promoting behaviours in general populations, but interventions merging exercise and peer support for older adults with cancer are not examined. The purpose of this study was to determine the feasibility and preliminary effectiveness of a virtual partner-based peer support exercise intervention for older adult female cancer survivors.

METHODS

Older adult female cancer survivors with internet access and currently participating in < 150 min of moderate-vigorous physical activity per week were included in this study. Participants were matched with a partner and given a peer support guide, exercise guidelines, and a Fitbit Inspire©. In addition, intervention group dyads (AgeMatchPLUS) had weekly 1-h virtual sessions with a qualified exercise professional for 10 weeks. Dyads randomized to the control group (AgeMatch) independently supported their partner around exercise for 10 weeks. The primary outcome was feasibility, measured using retention and adherence rates. Secondary outcomes included exercise volume, social support, quality of life, physical function, and physical activity enjoyment. Descriptive statistics were used to report feasibility and an ANCOVA was used to explore between group differences on secondary outcomes at post-intervention (10 weeks post baseline) and post-tapering timepoints (14 weeks post baseline).

RESULTS

Eighteen participants (9 dyads; mean age 72 years (SD: 5.7 years)) were included in the pilot trial. Retention and adherence rates to the AgeMatchPLUS intervention were 100% and 95% respectively. All but one participant was satisfied with the quality of their peer match. Preliminary effects were seen between group, favouring AgeMatchPLUS for exercise-related social support post-intervention (effect size (d) = 0.27, 95% CI = 0,0.54) and physical activity enjoyment at post-tapering (d = 0.25, 95% CI = 0,0.52) and favouring the AgeMatch group for 30 s sit-to-stand repetitions at post-tapering (d = 0.31, 95% CI = 0.004, 0.57). No other effects were found.

CONCLUSIONS

A virtual partner-based exercise intervention for older adults with cancer is feasible and shows preliminary effect benefits. Findings inform future trials aimed at increasing exercise in older adults with cancer.

TRIAL REGISTRATION

Clinicaltrials.gov (ID: NCT05549479, date: 22/09/22).

摘要

背景

有规律的锻炼可以减轻癌症治疗的副作用。然而，只有一小部分癌症患者符合运动指南，而年龄较大的患者（>65 岁）在癌症康复研究中代表性不足。同伴支持有助于促进一般人群的健康行为，但针对患有癌症的老年人的将锻炼和同伴支持相结合的干预措施尚未得到检验。本研究的目的是确定一种基于虚拟伙伴的同伴支持锻炼干预措施对老年女性癌症幸存者的可行性和初步效果。

方法

本研究纳入了有互联网接入且目前每周参加<150 分钟中等至剧烈体力活动的老年女性癌症幸存者。参与者与一名伙伴相匹配，并获得了同伴支持指南、锻炼指南和 Fitbit Inspire©。此外，干预组对（AgeMatchPLUS）每周与一名合格的运动专业人员进行 1 小时的虚拟会议，共进行 10 周。随机分配到对照组（AgeMatch）的对独立围绕锻炼支持他们的伙伴 10 周。主要结果是使用保留率和依从率来衡量可行性。次要结果包括锻炼量、社会支持、生活质量、身体功能和身体活动享受。使用描述性统计来报告可行性，并在干预后（基线后 10 周）和减药后时间点（基线后 14 周）使用协方差分析（ANCOVA）探索组间差异。

结果

18 名参与者（9 对；平均年龄 72 岁（SD：5.7 岁））参加了试点试验。AgeMatchPLUS 干预的保留率和依从率分别为 100%和 95%。除了一名参与者外，所有参与者对他们的同伴匹配都非常满意。组间初步效果显著，AgeMatchPLUS 在干预后与锻炼相关的社会支持（效果大小（d）=0.27，95%置信区间（CI）=0，0.54）和减药后身体活动享受（d=0.25，95%CI=0，0.52）方面具有优势，而 AgeMatch 组在减药后 30 秒坐站重复次数方面具有优势（d=0.31，95%CI=0.004，0.57）。没有发现其他效果。