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老年人的角质层含水量与 HbA1c 水平呈负相关。

Stratum corneum hydration levels are negatively correlated with HbA1c levels in the elderly Chinese.

机构信息

Department of Dermatology, Medical Center for Public Health of Puning, Puning City, China.

Dermatology Hospital, Southern Medical University, Guangzhou, China.

出版信息

J Diabetes. 2024 Oct;16(10):e70022. doi: 10.1111/1753-0407.70022.

DOI:10.1111/1753-0407.70022
PMID:39463020
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11513436/
Abstract

Highlights Stratum corneum hydration levels are negatively correlated with HbA1c levels and positively correlated with skin surface pH. Individuals with type 2 diabetes display lower levels of stratum corneum hydration. Because low stratum corneum hydration levels can increase circulating levels of proinflammatory cytokines, which are linked to the pathogenesis of type 2 diabetes, improvement in stratum corneum hydration can be an alternative approach in the management of type 2 diabetes.

摘要

要点 角质层水分含量与 HbA1c 水平呈负相关，与皮肤表面 pH 值呈正相关。2 型糖尿病患者的角质层水分含量较低。由于低角质层水分含量会增加促炎细胞因子的循环水平，而这些细胞因子与 2 型糖尿病的发病机制有关，因此改善角质层水分含量可能是 2 型糖尿病治疗的一种替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01c6/11513436/c9a934f5233e/JDB-16-e70022-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01c6/11513436/c9a934f5233e/JDB-16-e70022-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01c6/11513436/c9a934f5233e/JDB-16-e70022-g001.jpg

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本文引用的文献

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Immun Ageing. 2023 Feb 7;20(1):7. doi: 10.1186/s12979-023-00331-1.
2
Alterations in epidermal function in type 2 diabetes: Implications for the management of this disease.2 型糖尿病患者表皮功能的改变：对这种疾病管理的影响。
J Diabetes. 2022 Sep;14(9):586-595. doi: 10.1111/1753-0407.13303. Epub 2022 Aug 31.
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Stratum corneum hydration in healthy adult humans according to the skin area, age and sex: a systematic review and meta-analysis.
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J Eur Acad Dermatol Venereol. 2022 Oct;36(10):1713-1721. doi: 10.1111/jdv.18297. Epub 2022 Jun 22.
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A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid.一种富含神经酰胺 NP 和不同链长脂肪酸的脂质混合物有助于恢复外用皮质类固醇损伤的皮肤屏障功能。
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J Eur Acad Dermatol Venereol. 2019 Nov;33(11):2197-2201. doi: 10.1111/jdv.15540. Epub 2019 Mar 27.
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