Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, 2028 Doornfontein, South Africa.
Discov Med. 2024 Oct;36(189):1987-1997. doi: 10.24976/Discov.Med.202436189.183.
Diabetes mellitus (DM) and its associated complications, including diabetic kidney disease, neuropathy, and retinopathy, impose significant challenges on healthcare systems due to their high morbidity, mortality, and associated costs. Existing treatments often yield unsatisfactory clinical outcomes, underscoring the need for innovative approaches to mitigate debilitating effects on patients' health-related quality of life. Photobiomodulation (PBM) is a non-invasive treatment that utilizes specific wavelengths of light in the treatment of various medical complications associated with DM. The specific wavelength used during PBM is critical in determining the therapeutic outcomes for managing diabetic complications. This paper aimed to explore the therapeutic potential of PBM in the management of diabetic complications, focusing on blue, red, and near-infrared (NIR) wavelengths. Relevant literature from Google Scholar, PubMed and ClinicalTrials databases from inception to date was searched using the keywords 'photobiomodulation', 'diabetes', 'diabetic complications', 'wound healing', 'neuropathy', 'retinopathy', and 'chronic wounds'. Red and NIR wavelengths are commonly used for a range of complications, while blue light has primarily been explored for treating diabetic wounds due to its antimicrobial nature. PBM treatment parameters for the same diabetic complication vary across clinical trials and preclinical research, with minimal clinical trials conducted on most diabetic complications. This inconsistency hinders the establishment of standardized PBM parameters, particularly concerning the optimal application setting.
糖尿病（DM）及其相关并发症，包括糖尿病肾病、神经病变和视网膜病变，由于其高发病率、死亡率和相关费用，给医疗保健系统带来了巨大挑战。现有的治疗方法往往产生不理想的临床效果，这突显了需要创新方法来减轻对患者健康相关生活质量的不利影响。光生物调节（PBM）是一种非侵入性治疗方法，利用特定波长的光治疗与 DM 相关的各种医疗并发症。PBM 过程中使用的特定波长对于确定管理糖尿病并发症的治疗效果至关重要。本文旨在探讨 PBM 在管理糖尿病并发症方面的治疗潜力，重点关注蓝色、红色和近红外（NIR）波长。使用关键词 '光生物调节'、'糖尿病'、'糖尿病并发症'、'伤口愈合'、'神经病变'、'视网膜病变' 和 '慢性伤口'，从 Google Scholar、PubMed 和 ClinicalTrials 数据库中搜索从成立到现在的相关文献。红色和 NIR 波长常用于一系列并发症，而蓝色光主要因其抗菌特性而被用于治疗糖尿病性伤口。对于同一糖尿病并发症，PBM 治疗参数在临床试验和临床前研究中存在差异，大多数糖尿病并发症的临床试验很少。这种不一致性阻碍了标准化 PBM 参数的建立，特别是关于最佳应用设置的参数。
