Samaras Menelaos G, Koufopoulos Nektarios Ι, Mitsos Sofoklis, Dylja Eris, Monokrousou Athanasia, Tomos Periklis, Panayiotides Ioannis G, Goutas Dimitrios
Department of Pathology, School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Department of Thoracic Surgery, University College London Hospitals NHS Foundation Trust, London, GBR.
Cureus. 2024 Sep 27;16(9):e70309. doi: 10.7759/cureus.70309. eCollection 2024 Sep.
Lymphoepithelial or lymphoepithelioma-like carcinoma is a poorly differentiated carcinoma located outside the nasopharynx with similar morphologic characteristics to its nasopharyngeal counterpart. Lymphoepithelial carcinoma of the lung is a rare subtype of squamous cell lung carcinoma frequently associated with Epstein-Barr virus (EBV) infection, accounting for approximately 1% of non-small cell lung carcinomas (NSCLC). We herewith present a case of a 78-year-old female patient who was diagnosed with lymphoepithelial carcinoma of the lung, emphasizing its distinct epidemiological features, clinical workup, and histopathological characteristics. Furthermore, we discuss its histologic differential diagnosis. Finally, we refer to this tumor's unique molecular and immunological profile and its treatment modalities, and we review the literature.
淋巴上皮或淋巴上皮瘤样癌是一种位于鼻咽部以外的低分化癌，其形态学特征与其鼻咽部对应物相似。肺淋巴上皮癌是肺鳞状细胞癌的一种罕见亚型，常与爱泼斯坦-巴尔病毒（EBV）感染相关，约占非小细胞肺癌（NSCLC）的1%。我们在此报告一例78岁女性患者，她被诊断为肺淋巴上皮癌，强调其独特的流行病学特征、临床检查和组织病理学特征。此外，我们讨论了其组织学鉴别诊断。最后，我们提及该肿瘤独特的分子和免疫特征及其治疗方式，并对文献进行了综述。
