Deigan E A, Carmichael J A, Ohlke I D, Karchmar J
Am J Obstet Gynecol. 1986 Feb;154(2):255-9. doi: 10.1016/0002-9378(86)90650-2.
From 1973 to 1984, 776 patients with cervical intraepithelial neoplasia were treated with outpatient electrocautery (hot cautery) without anesthesia. Of these, 726 (94%) were available for follow-up in 3 to 6 months. An initial cure rate with one treatment of 89% to 90% was achieved. Cure rates were similar for all degrees of dysplasia, including carcinoma in situ. There were no complications. All patients with failure of the initial treatment who returned for further outpatient management were eventually cured with use of electrocautery. Long-term follow-up rates ranged from 75% at 1 year to 46% at 5 years. There were few late recurrences, most of which were treated again (successfully) with electrocautery. Electrocautery produces cure rates similar to those for other forms of conservative management and may be the most cost-effective method of management of cervical intraepithelial neoplasia.
1973年至1984年期间,776例宫颈上皮内瘤变患者接受了无麻醉的门诊电灼术(热灼术)治疗。其中,726例(94%)患者在3至6个月时接受了随访。单次治疗的初始治愈率达到89%至90%。所有程度的发育异常,包括原位癌,治愈率相似。未出现并发症。所有初次治疗失败后返回接受进一步门诊治疗的患者最终均通过电灼术治愈。长期随访率从1年时的75%到5年时的46%不等。晚期复发很少,大多数复发再次(成功)接受了电灼术治疗。电灼术的治愈率与其他形式的保守治疗相似,可能是治疗宫颈上皮内瘤变最具成本效益的方法。