Li Yanni, Chen Lin, Chen Yonghao, Shi Hongxing, Yu Sheng, Funmilayo Adeleye, Wu Chao, Wang Chunhui, Deng Yi
West China Hospital, School of Chemical Engineering, Sichuan University, Chengdu, 610041, China; Department of Gastroenterology and Hepatology, West China Hospital of Sichuan University, Chengdu, 610041, China.
West China Hospital, School of Chemical Engineering, Sichuan University, Chengdu, 610041, China.
Biomaterials. 2025 Apr;315:122921. doi: 10.1016/j.biomaterials.2024.122921. Epub 2024 Oct 25.
Photothermal and photodynamic therapies represent effective modalities for combatting bacteria and tumor cells. However, therapeutic outcomes are constrained by limitations related to the heat and reactive oxygen species (ROS) transfer distance from photosensitizers to targets. To address this issue, we have devised and developed exosome-decorated bio-heterojunctions (E-bioHJ) consisted of MXene (TiC), liquid metal (LM) and exosomes sourced from CT26 cells to enhance the phototherapeutic consequences. Engineering E-bioHJ enhances phototherapeutic effect in antibacterial and anti-tumor treatment, which is ascribed to reducing transfer distance of the heat and ROS. When adorned with exosomes, E-bioHJ is targetedly delivered into the cytoplasm of tumor cells to generate amount heat and ROS under 808 nm near-infrared radiation, which further induces mitochondrial dysfunction and apoptosis/necroptosis. As envisaged, this study presents a novel tactic to enhance the antibacterial and anti-tumor efficacy of biomaterials through reducing the heat and ROS delivery travel distance.
光热疗法和光动力疗法是对抗细菌和肿瘤细胞的有效方式。然而，治疗效果受到与热量和活性氧（ROS）从光敏剂到靶点的转移距离相关的限制。为了解决这个问题，我们设计并开发了由MXene（TiC）、液态金属（LM）和源自CT26细胞的外泌体组成的外泌体修饰生物异质结（E-bioHJ），以增强光疗效果。构建E-bioHJ可提高抗菌和抗肿瘤治疗中的光疗效果，这归因于缩短了热量和ROS的转移距离。当用外泌体修饰时，E-bioHJ被靶向递送至肿瘤细胞的细胞质中，在808nm近红外辐射下产生大量热量和ROS，进而诱导线粒体功能障碍和凋亡/坏死性凋亡。正如所设想的那样，本研究提出了一种通过缩短热量和ROS传递行程距离来提高生物材料抗菌和抗肿瘤功效的新策略。
