Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Neurosurg Rev. 2024 Oct 29;47(1):827. doi: 10.1007/s10143-024-03060-1.
Applications of radiomics for clinical management of medulloblastomas are expanding. This systematic review aims to aggregate and overview the current role of radiomics in the diagnosis, subtyping, and prognostication of medulloblastomas. The present systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed/MEDLINE were searched using a standardized search term. Articles found within the database from the inception until November 2022 were considered for screening. Retrieved records were screened independently by two authors based on their titles and abstracts. The full text of selected articles was reviewed to finalize the eligibility. Due to the heterogeneity of included studies, no formal data synthesis was conducted. Of the 249 screened citations, 21 studies were included and analyzed. Radiomics demonstrated promising performance for discriminating medulloblastomas from other posterior fossa tumors, particularly ependymomas and pilocytic astrocytomas. It was also efficacious in determining the subtype (i.e., WNT+, SHH+, group 3, and group 4) of medulloblastomas non-invasively. Regarding prognostication, radiomics exhibited some ability to predict overall survival and progression-free survival of patients with medulloblastomas. Our systematic review revealed that radiomics represents a promising tool for diagnosis and prognostication of medulloblastomas. Further prospective research measuring the clinical value of radiomics in this setting is warranted.
放射组学在髓母细胞瘤临床管理中的应用正在不断扩展。本系统综述旨在综合概述放射组学在髓母细胞瘤的诊断、亚型分类和预后评估中的当前作用。本系统综述是按照系统评价和荟萃分析的首选报告项目（PRISMA）指南进行的。使用标准化的搜索术语对 PubMed/MEDLINE 进行了搜索。从数据库建立到 2022 年 11 月期间发现的文章被考虑进行筛选。根据标题和摘要，由两位作者独立筛选检索记录。对选定文章的全文进行了回顾，以确定其是否符合入选标准。由于纳入研究的异质性，未进行正式的数据综合。在 249 篇筛选出的引文中有 21 篇被纳入并进行了分析。放射组学在区分髓母细胞瘤与其他后颅窝肿瘤（特别是室管膜瘤和毛细胞型星形细胞瘤）方面表现出有前景的性能。它还能有效地确定髓母细胞瘤的亚型（即 WNT+、SHH+、第 3 组和第 4 组）。关于预后，放射组学在预测髓母细胞瘤患者的总生存率和无进展生存率方面显示出一定的能力。我们的系统综述表明，放射组学是髓母细胞瘤诊断和预后的一种很有前途的工具。有必要进行进一步的前瞻性研究，以衡量放射组学在这一领域的临床价值。
