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肥胖相关的癌症驱动突变选择。

Obesity-dependent selection of driver mutations in cancer.

机构信息

Computational Oncology Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

出版信息

Nat Genet. 2024 Nov;56(11):2318-2321. doi: 10.1038/s41588-024-01969-3. Epub 2024 Oct 28.

DOI:10.1038/s41588-024-01969-3
PMID:39468367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11549034/
Abstract

Obesity is a risk factor for cancer, but whether obesity is linked to specific genomic subtypes of cancer is unknown. We examined the relationship between obesity and tumor genotype in two clinicogenomic corpora. Obesity was associated with specific driver mutations in lung adenocarcinoma, endometrial carcinoma and cancers of unknown primaries, independent of clinical covariates, demographic factors and genetic ancestry. Obesity is therefore a driver of etiological heterogeneity in some cancers.

摘要

肥胖是癌症的一个风险因素，但肥胖是否与癌症的特定基因组亚型有关尚不清楚。我们在两个临床基因组数据库中研究了肥胖与肿瘤基因型之间的关系。肥胖与肺腺癌、子宫内膜癌和不明原发灶癌症的特定驱动基因突变有关，与临床协变量、人口统计学因素和遗传背景无关。因此，肥胖是某些癌症病因异质性的一个驱动因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a68/11549034/1c832249cf7c/41588_2024_1969_Fig3_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a68/11549034/776d1191e52f/41588_2024_1969_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a68/11549034/2875f52a050a/41588_2024_1969_Fig2_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a68/11549034/1c832249cf7c/41588_2024_1969_Fig3_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a68/11549034/776d1191e52f/41588_2024_1969_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a68/11549034/2875f52a050a/41588_2024_1969_Fig2_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a68/11549034/1c832249cf7c/41588_2024_1969_Fig3_ESM.jpg

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Body Mass Index and Sporadic Medullary Thyroid Cancer: Insights from a Large Series.体重指数与散发性甲状腺髓样癌：来自大量病例系列的见解
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