van Oeteren Michelle A J, Simons Nynke, Simons Pomme I H G, van de Waarenburg Marjo P H, Kooi M Eline, Feskens Edith J M, van der Ploeg E M C Liesbeth, Van den Eynde Mathias D G, Houben Alfons J H M, Schalkwijk Casper G, Brouwers Martijn C G J
Laboratory for Metabolism and Vascular Medicine, Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Clin Obes. 2025 Feb;15(1):e12714. doi: 10.1111/cob.12714. Epub 2024 Oct 28.
We aimed to examine the effects of isocaloric fructose restriction on adipose tissue distribution and serum adipokines. Individuals with BMI >28 kg/m (n = 44) followed a 6-week fructose-restricted diet and were randomly allocated to (double-blind) oral supplementation with fructose (control) or glucose (intervention) powder three times daily. Visceral (VAT) and subcutaneous (SAT) adipose tissue was quantified with MRI. Serum interleukin 6 and 8, tumour necrosis factor alpha and adiponectin levels were measured with sandwich immunoassay. BMI decreased in both groups, but the change did not differ between groups (-0.1 kg/m, 95%CI: -0.3; 0.5). SAT decreased statistically significantly in the control group (-23.2 cm, 95%CI: -49.4; -4.1), but not in the intervention group. The change in SAT did not differ between groups (29.6 cm, 95%CI: -1.2; 61.8). No significant differences in VAT were observed within or between study arms. The VAT/SAT ratio decreased statistically significantly in the intervention group (-0.02, 95%CI: -0.04; -0.003) and the change was significantly different between groups (-0.03, 95%CI: -0.54; -0.003). Serum adipokine levels were not affected by the intervention. This study shows that a fructose-restricted diet resulted in a favourable change in adipose tissue distribution, but did not affect serum adipokines. Further studies are warranted to clarify the underlying mechanisms how fructose affects adipose tissue distribution.
我们旨在研究等热量果糖限制对脂肪组织分布和血清脂肪因子的影响。体重指数（BMI）>28kg/m²的个体（n = 44）遵循为期6周的果糖限制饮食，并被随机分配至（双盲）每日三次口服补充果糖（对照组）或葡萄糖（干预组）粉末。通过磁共振成像（MRI）对内脏脂肪组织（VAT）和皮下脂肪组织（SAT）进行定量。采用夹心免疫分析法测定血清白细胞介素6和8、肿瘤坏死因子α和脂联素水平。两组的BMI均下降，但组间变化无差异（-0.1kg/m²，95%置信区间：-0.3；0.5）。对照组的SAT有统计学显著下降（-23.2cm，95%置信区间：-49.4；-4.1），但干预组没有。两组间SAT的变化无差异（29.6cm，95%置信区间：-1.2；61.8）。在研究组内或组间，VAT均未观察到显著差异。干预组的VAT/SAT比值有统计学显著下降（-0.02，95%置信区间：-0.04；-0.003），且组间变化有显著差异（-0.03，95%置信区间：-0.54；-0.003）。血清脂肪因子水平不受干预影响。本研究表明，果糖限制饮食导致脂肪组织分布出现有利变化，但不影响血清脂肪因子。有必要进行进一步研究以阐明果糖影响脂肪组织分布的潜在机制。
