血清茶碱和苯妥英水平：我们能承担检测它们的费用吗？我们能承担不检测的后果吗？

Serum theophylline and phenytoin levels: can we afford to do them? Can we afford not to?

作者信息

Kuhn G

出版信息

Ann Emerg Med. 1986 Mar;15(3):344-8. doi: 10.1016/s0196-0644(86)80582-0.

Abstract

The following factors must be considered when determining the need for theophylline and diphenylhydantoin (DPH) levels: accuracy and reproducibility, turnaround time, and cost-benefit ratio for the patient. Serum levels must bear a relationship to the therapeutic effects of the drugs. In addition, the pharmacology of the drugs must be of such an order of complexity that there is not a simple relationship between dosage and serum levels.

摘要

在确定是否需要检测茶碱和苯妥英（DPH）血药浓度时，必须考虑以下因素：检测结果的准确性和可重复性、周转时间以及对患者的成本效益比。血药浓度必须与药物的治疗效果相关。此外，药物的药理学特性必须具有一定的复杂性，使得剂量与血药浓度之间不存在简单的关系。