高压液相色谱法测定血清茶碱的临床应用
Clinical applications of serum theophylline measurement by high pressure liquid chromatography.
作者信息
McKenzie S A, Edmunds A T, Baillie E, Meek J H
出版信息
Arch Dis Child. 1978 Apr;53(4):322-5. doi: 10.1136/adc.53.4.322.
Abstract
Serum theophylline concentration was measured in children both during treatment of status asthmaticus with intravenous aminophylline, and as outpatients while they were taking oral theophylline compounds for long-term management of asthma. The clinical value of the measurements was assessed. Measurement using high-pressure liquid chromatography is simple and requires only a small volume of blood. Knowledge of serum theophylline concentration facilitates careful control of dosage of both intravenous aminophylline during treatment of status asthmaticus, and of oral theophylline in outpatients. It is useful in the evaluation of symptoms which may be due to toxic side effects of treatment. It also makes possible an assessment of patient compliance with prescribed treatment among those whose symptoms have not improved.
摘要
在儿童静脉注射氨茶碱治疗哮喘持续状态期间以及作为门诊患者服用口服茶碱化合物进行哮喘长期管理时，均测定了血清茶碱浓度。对这些测量的临床价值进行了评估。使用高压液相色谱法进行测量很简单，只需要少量血液。了解血清茶碱浓度有助于在哮喘持续状态治疗期间仔细控制静脉注射氨茶碱的剂量，以及门诊患者口服茶碱的剂量。它有助于评估可能由治疗毒性副作用引起的症状。对于症状未改善的患者，它还可以评估患者对规定治疗的依从性。
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