Department of Hematology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Department of General Practice, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Front Immunol. 2024 Oct 14;15:1467506. doi: 10.3389/fimmu.2024.1467506. eCollection 2024.
Lymphoid proliferations and lymphomas arising in post-transplantation are potentially life-threatening complications after solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT). The lymphoid proliferations and lymphomas arising in post-transplantation originating from different cell lineages in the same patient are highly unusual. Herein, we delineate a case of isolated spinal cord involvement with B cell lymphoid proliferations and lymphomas arising in post-transplantation at 11 months post-transplantation, which was successfully treated with chemotherapy and intrathecal injection. Six months later, the patient again developed lymphoma arising in post-transplantation, presenting with predominant subcutaneous tissue involvement deriving from EBV-positive NK/T cells, and received four courses of chemotherapy. Ultimately, she achieved complete remission (CR). The report further contributes to our new insights into the unusual clinical presentations of lymphoid proliferations and lymphomas arising in post-transplantation.
移植后发生的淋巴增生和淋巴瘤是实体器官移植（SOT）和造血干细胞移植（HSCT）后潜在的危及生命的并发症。同一患者源自不同细胞谱系的移植后发生的淋巴增生和淋巴瘤极为罕见。在此，我们描述了一例在移植后 11 个月发生的孤立性脊髓受累伴 B 细胞淋巴增生和淋巴瘤的病例，该病例经化疗和鞘内注射成功治疗。6 个月后，患者再次发生移植后淋巴瘤，表现为源自 EBV 阳性 NK/T 细胞的主要皮下组织受累，并接受了 4 个疗程的化疗。最终，她达到完全缓解（CR）。该报告进一步为我们提供了对移植后淋巴增生和淋巴瘤的不常见临床表现的新认识。
